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2,5-hexanedione

Known as: diacetonyl, 2,5-diketohexane, hexanedione, 2,5- 
 
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
Studies have shown that 2,5-hexanedione (2,5-HD) is the main active metabolite of n-hexane in the human body. The toxicity of n… Expand
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Highly Cited
2009
Highly Cited
2009
Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease due to mitochondrial DNA (mtDNA) point… Expand
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Highly Cited
2002
Highly Cited
2002
This research was conducted to determine which neurological test or combination of tests can provide sufficient functional… Expand
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Highly Cited
1999
Highly Cited
1999
Sertoli cells, the supportive cells in the seminiferous epithelium, orchestrate spermatogenesis by providing structural and… Expand
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Review
1997
Review
1997
Protein covalent binding by xenobiotic metabolites has long been associated with target organ toxicity but mechanistic… Expand
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Highly Cited
1983
Highly Cited
1983
The neurotoxic hexacarbon 2,5-hexanedione (2,5-HD) produces testicular atrophy in experimental animals. To examine the… Expand
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Review
1982
Review
1982
  • D. Couri, M. Milks
  • Annual review of pharmacology and toxicology
  • 1982
  • Corpus ID: 24622614
Human exposure to hexacarbon compounds is quite pervasive, including occupational exposures to industrial solvents as well as… Expand
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Highly Cited
1982
Highly Cited
1982
Abstract The industrial solvents n -hexane and methyl n -butyl ketone are metabolized to the neurotoxic γ-diketone 2,5… Expand
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Highly Cited
1975
Highly Cited
1975
Chronic exposure of rats to 2,5-hexanedione (CH3COCH2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n… Expand
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Highly Cited
1974
Highly Cited
1974
The spatio-temporal pattern of distal peripheral nerve, sensory and motor nerve terminal, degeneration in experimental acrylamide… Expand
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