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2,5-hexanedione

Known as: diacetonyl, 2,5-diketohexane, hexanedione, 2,5- 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

Cholinesterase InhibitorsCross-Linking ReagentsHexanonesNeurotoxins

Papers overview

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Highly Cited
1996
Highly Cited
1996
Fate of germ cells in 2,5-hexanedione-induced testicular injury. I. Apoptosis is the mechanism of germ cell death.
2,5-hexanedione (2,5-HD) is a Sertoli cell toxicant which causes germ cell loss and testicular atrophy in the rat. The mechanism… 
1987
1987
Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size
Highly Cited
1986
Highly Cited
1986
Cross‐Linking of Neurofilament Proteins of Rat Spinal Cord In Vivo After Administration of 2,5‐Hexanedione
The aliphatic hexacarbons n‐hexane, methyl‐nbutyl ketone, and 2,5‐hexanedione are known to produce a peripheral neuropathy that… 
Highly Cited
1983
Highly Cited
1983
Cytoskeletal disorganization induced by local application of β,β′‐iminodipropionitrile and 2,5‐hexanedione
β,β′‐Iminodipropionitrile and 2,5‐hexanedione are neurotoxins that produce neurofilamentous axonal swellings. The swellings… 
Highly Cited
1983
Highly Cited
1983
The Spatio‐Temporal Pattern of the Axonopathy Associated with the Neurotoxicity of 3,4‐Dimethyl-2,5‐Hexanedione in the Rat
The neurotoxicity of the γ-diketone 3,4-dimethyl-2,5-hexanedione(DMHD) was studied to determine the distribution of the… 
1981
1981
Dose-dependent uptake, distribution, and elimination of inhaled n-hexane in the Fischer-344 rat.
Highly Cited
1980
Highly Cited
1980
Identification of the metabolites of n-hexane, cyclohexane, and their isomers in men's urine.
Highly Cited
1980
Highly Cited
1980
Ultrastructural studies of the dying-back process. V. Axonal neurofilaments accumulate at sites of 2,5-hexanedione application: Evidence for nerve fibre dysfunction in experimental hexacarbon…
SummaryThis study examines the thesis that 2,5-hexanedione (2,5-HD) produces distal (dying-back) axonopathy by direct toxic… 
Highly Cited
1977
Highly Cited
1977
Metabolic fate and disposition of 14C-labeled methyl n-butyl ketone in the rat.
Highly Cited
1975
Highly Cited
1975
Experimental neuropathy produced by 2,5-hexanedione--a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone.
Chronic exposure of rats to 2,5-hexanedione (CH3COCH2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n… 
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