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2,4-diaminohypoxanthine

Known as: 2,4-DAHP, 2,4-diamino-6-hydroxypyrimidine, DHAP-2,4 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Enzyme InhibitorsHypoxanthines

Papers overview

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Highly Cited
2010
Highly Cited
2010
Synthesis and biological activity of a novel series of 6-substituted pyrrolo[2,3- d ]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate…
2-Amino-4-oxo-6-substituted pyrrolo[2,3- d ]pyrimidines with a thienoyl side chain and 4-6 carbon bridge lengths (compounds 1-3… 
Highly Cited
2003
Highly Cited
2003
Lack of Nitric Oxide Mediation of Flow-Dependent Arteriolar Dilation in Type I Diabetes Is Restored by Sepiapterin
The mechanisms leading to microangiopathy in diabetes mellitus have still not been clearly elucidated. We hypothesized that type… 
Highly Cited
1997
Highly Cited
1997
Inhibition of tetrahydrobiopterin biosynthesis impairs endothelium-dependent relaxations in canine basilar artery.
Tetrahydrobiopterin is an essential cofactor in biosynthesis of nitric oxide. The present study was designed to determine the… 
1997
1997
Involvement of nitric oxide in the interferon-γ-induced inhibition of growth hormone and prolactin secretion in anterior pituitary cell cultures
Highly Cited
1996
Highly Cited
1996
Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin.
BACKGROUND A deficit in the endothelial production of nitric oxide (NO) is associated with the sequelae of reperfusion injury… 
1994
1994
Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle.
We recently reported (Am. J. Respir. Cell Mol. Biol. 7: 471-476, 1992) that a mixture of lipopolysaccharide (LPS) and cytokines… 
Highly Cited
1994
Highly Cited
1994
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
Classical antifolate analogues containing a novel furo[2,3-d]pyrimidine ring system which include N-[4-[N-[(2,4-diaminofuro[2,3-d… 
Highly Cited
1993
Highly Cited
1993
Regulation of the L-arginine-dependent and tetrahydrobiopterin-dependent biosynthesis of nitric oxide in murine macrophages.
Nitric oxide is a recently discovered biomolecule with a broad range of actions. The present study investigated the regulation of… 
1992
1992
New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines.
1984
1984
Tetrahydrobiopterin and Total Biopterin Content of Neuroblastoma (N1E‐115, N2A) and Pheochromocytoma (PC‐12) Clones and the Dependence of Catecholamine Synthesis on Tetrahydrobiopterin Concentration…
Abstract: Tetrahydrobiopterin content was determined in several clonal cell lines by reversed‐phase HPCL and subsequent… 
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