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Mitochondrial toxicity can result from antiviral nucleotide analog therapy used to control human immunodeficiency virus type 1… Expand The mechanism by which DNA polymerase I enzymes function has been the subject of extensive biochemical and structural studies. We… Expand Xeroderma pigmentosum variant (XP‐V) represents one of the most common forms of this cancer‐prone DNA repair syndrome. Unlike… Expand The ribonucleoprotein enzyme telomerase is a specialized type of cellular reverse transcriptase which synthesizes one strand of… Expand Telomerase activity was identified in extracts from several different mouse cell lines. Addition of telomeric TTAGGG repeats was… Expand Nuclear extracts derived from HeLa and Drosophila melanogaster KC cell lines have been found to correct single base-base mispairs… Expand The muscle mitochondria of a patient with Kearns-Sayre/chronic external ophthalmoplegia plus syndrome were found to be completely… Expand Previous studies on the biological effects of the 2′,3′‐dideoxynucleosides (ddNs) have shown that while ddAdo is lethal to E… Expand The involvement of DNA polymerases alpha, beta, and gamma in DNA repair synthesis was investigated in subcellular preparations of… Expand An in vitro adenovirus DNA replication system catalyzed the formation of a covalent complex between an 80,000-dalton protein and… Expand