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1-chloromethylpyrene

National Institutes of Health

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Pyrenes

Papers overview

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1996
1996
Detection of gene mutation in skin, stomach and liver of MutaMouse following oral or topical treatment with N-methyl-N'-nitro-N-nitrosoguanidine or 1-chloromethylpyrene: some preliminary observations…
Transgenic mouse assays, such as MutaMouse, provide a method to predict the potential target organ carcinogenicity of chemical… 
1993
1993
Sulfotransferase-mediated mutagenicity of 1-hydroxymethylpyrene and 4H-cyclopenta[def]chrysen-4-ol and its enhancement by chloride anions.
1-Hydroxymethylpyrene (HMP), a primary benzylic alcohol, and 4H-cyclopenta[def]chrysen-4-ol (OH-CPC), a secondary benzylic… 
1993
1993
Genotoxic activity of 1-chloromethylpyrene in stomach epithelium in vivo: insensitivity of the stomach scintillation UDS assay.
An acknowledged weakness of current testing programmes for genotoxic hazard has been the potential insensitivity of the… 
Highly Cited
1990
Highly Cited
1990
Metabolic activation of 9-hydroxymethyl-10-methylanthracene and 1-hydroxymethylpyrene to electrophilic, mutagenic and tumorigenic sulfuric acid esters by rat hepatic sulfotransferase activity.
Our previous studies on 7-hydroxymethyl-12-methylbenz[a]anthracene and 6-hydroxymethylbenzo[a]pyrene showed that cytosolic… 
1990
1990
1-Chloromethylpyrene: a reference skin sensitizer and genotoxin.
1987
1987
Mutagenicity studies of alpha, alpha'-dihalomethylbenzenes, alpha-methylbenzyl halides, and 1-chloromethylpyrene in the Ames assay.
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