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Metabolic activation of 9-hydroxymethyl-10-methylanthracene and 1-hydroxymethylpyrene to electrophilic, mutagenic and tumorigenic sulfuric acid esters by rat hepatic sulfotransferase activity.
SMA and SMP were weak skin tumor initiators in the mouse, but they were more active than HMA and HMP in this regard and chloride ion at physiological concentrations enhanced the bacterial mutagenicity of SMA through the formation of 9-chloromethyl-10-methylanthracene as previously observed for SMP by Henschler et al.
Isolation and Characterization of a Galactosamine Wall from Spores and Spherules of Physarum polycephalum
The presence of a rare galactosamine polymer in P. polycephalum spore and spherule walls as the only carbohydrate suggests that the myxomycetes are not closely related to the fungi or the protozoa.
Anaphase Delay after Inhibition of Protein Synthesis between Late Prophase and Prometaphase
Proteins that determine the duration of the transition from metaphase to nuclear reconstruction were synthesized from late prophase to prometaphase, and it is proposed that these proteins are concerned with the transformation of chemical energy into the mechanical work of mitosis.
Isolation and Characterization of an Extracellular Polysaccharide from Physarum polycephalum
The increased synthesis of slime during spherulation was not blocked by cycloheximide, suggesting that new enzyme synthesis was not necessary for its formation, and increased absorbance at 820 cm(-1) characteristic of C-O-S vibrations was shown.
Apurinic/apyrimidinic site induction in supercoiled DNA and mutagenesis in Salmonella typhimurium TA100 by 1'-acetoxysafrole and related electrophilic alkenylbenzene derivatives.
The abilities of seven electrophilic alkenylbenzene derivatives related to 1'-acetoxysafrole to induce apurinic/apyrimidinic (AP) sites in supercoiled SV40 DNA were quantitated by gel electrophoresis
Activation of 1-hydroxymethylpyrene to an electrophilic and mutagenic metabolite by rat hepatic sulfotransferase activity.
Hydroxylation of meso-methyl groups with subsequent formation of reactive benzylic esters bearing a good leaving group has been proposed as a possible activation pathway in the DNA binding and carcinogenicity of some methyl-substituted polycyclic aromatic hydrocarbons.