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Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
- E. Miller, A. Swanson, D. Phillips, T. Fletcher, A. Liem, J. Miller
- Chemistry, BiologyCancer research
- 1 March 1983
Twenty-three naturally occurring and synthetic alkenylbenzene derivatives structurally related to the hepatocarcinogen safrole were assayed for their hepatocARCinogenicity in mice to identify benign skin tumors that could be promoted with croton oil.
Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene
HPV-16 E7 can alter epithelial cell growth parameters sufficiently to potentiate tumorigenesis in mice, and this hypothesis that E6 and E7 contribute to cervical carcinogenesis is concluded.
Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice.
Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver.
Data strongly support the conclusion that 1'-sulfoöxysafrole is the major ultimate electrophilic and tumor-initiating metabolite of 1'-hydroxysaf role.
5-Sulfooxymethylfurfural as a possible ultimate mutagenic and carcinogenic metabolite of the Maillard reaction product, 5-hydroxymethylfurfural.
5-Chloromethylfurfural was found to be a strong hepatocarcinogen in infant male B6C3F1 mice and induced dose-dependent increases in the number of His+ revertants in Salmonella typhimurium TA100.
Vinyl carbamate epoxide, a major strong electrophilic, mutagenic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate (urethane).
Data and those from other recent studies support the conclusion that VCO is a major strong electrophilic, mutagenic and carcinogenic metabolite of EC and VC in the mouse.
Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.
- P. Lambert, H. Pan, H. Pitot, A. Liem, M. Jackson, A. Griep
- Biology, MedicineProceedings of the National Academy of Sciences…
- 15 June 1993
Evidence is provided that expression of the E6 and E7 genes from the high-risk HPV-16 in the skin of transgenic mice potentiated the development of preneoplastic lesions, and a high percentage of these epidermal lesions subsequently developed into locally invasive cancers.
Chemoprotective effects of capsaicin and diallyl sulfide against mutagenesis or tumorigenesis by vinyl carbamate and N-nitrosodimethylamine.
- Y. Surh, R. C. Lee, K. K. Park, S. Mayne, A. Liem, J. Miller
- Biology, ChemistryCarcinogenesis
- 1 October 1995
The results of this study suggest that capsaicin and diallyl sulfide suppress VC- and NDMA-induced mutagenesis or tumorigenesis in part through inhibition of the cytochrome P-450 IIE1 isoform responsible for activation of these carcinogens.
Metabolic activation of 9-hydroxymethyl-10-methylanthracene and 1-hydroxymethylpyrene to electrophilic, mutagenic and tumorigenic sulfuric acid esters by rat hepatic sulfotransferase activity.
SMA and SMP were weak skin tumor initiators in the mouse, but they were more active than HMA and HMP in this regard and chloride ion at physiological concentrations enhanced the bacterial mutagenicity of SMA through the formation of 9-chloromethyl-10-methylanthracene as previously observed for SMP by Henschler et al.
Impaired antigen presentation and effectiveness of combined active/passive immunotherapy for epithelial tumors.
- Koji Matsumoto, G. Leggatt, I. Frazer
- Biology, MedicineJournal of the National Cancer Institute
- 3 November 2004
Antigen-specific CD8+ T cells can destroy epithelium expressing HPV16 E7 tumor antigen, but presentation of E7 antigen from skin is insufficient to reactivate memory T cells induced by immunotherapy, suggesting effective cancer immunotherapy in humans may need to invoke sufficient effector as well as memory T Cells.