The number and function of circulating endothelial progenitor cells in patients with Kawasaki disease

@article{Xu2010TheNA,
  title={The number and function of circulating endothelial progenitor cells in patients with Kawasaki disease},
  author={Mingguo Xu and Li Na Men and Chun-yu Zhao and Xia Zhao and Yuan-xiang Wang and Xiang-Chun Meng and Ding-rong Shen and Baoying Meng and Qing Zhang and Tao Wang},
  journal={European Journal of Pediatrics},
  year={2010},
  volume={169},
  pages={289-296},
  url={https://api.semanticscholar.org/CorpusID:5953056}
}
The two-way regulation of circulating EPC in KD patients may be associated with the disorders of cytokines or messengers in KDPatients and the functions of EPC were attenuated in Kawasaki disease.
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27 Citations
Highly Influential Citations
2
Background Citations
7
Methods Citations
3
Results Citations
1

27 Citations

The Functions of Endothelial Progenitor Cells Were Significantly Improved After Treatment With Intravenous Immunoglobulin and Aspirin in Children With Kawasaki Disease

The results of this study indicate that the functions of circulating EPCs improved after treatment with IVIG and aspirin, which may be related to decreased concentrations of TNF-α and hs-CRP.

Number and function of circulating endothelial progenitor cells in patients with primary Budd-Chiari syndrome.

Markers of endothelial damage and repair in Takayasu arteritis: Are they associated with disease activity?

Increased level of CEC in patients with Takayasu arteritis is shown, and it is suggested that the CEPC and VEGF levels may be correlated with disease activity, which is in line with current clinical and laboratory parameters.

Markers of Endothelial Dysfunction in Kawasaki Disease: An Update

Insight is provided into the current understanding of the significance of ED in KD and biomarkers such as oxidative stress markers, circulating cells and their progenitors, angiogenesis factors, cytokines, chemokines, cell-adhesion molecules, and adipokines may be useful for monitoring the disease course of KD.

Endothelial injury and repair in systemic vasculitis of the young.

Elevation of the levels of CECs, EMPS, EPCs, VEGF, and Ang-2 occurs during active vasculitis in children, and the levels declined with remission-inducing therapy in the individual patients.

The Circulating Level of Endothelial Progenitor Cells After Transcatheter Closure of Congenital Heart Disease in Children

The results showed that transcatheter closure of PDA and ASD in children does not lead to increased circulating level of EPCs, and may result in vascular endothelium injury as indicated by increased circulating EPC level.

Granulocyte colony‐stimulating factor ameliorates coronary artery elastin breakdown in a mouse model of Kawasaki disease

The present study indicated that the administration of G‐CSF prevents elastin breakdown of the coronary arteries by enhancing the number and functions of EPCs via the NO system, and then accelerates the repair of coronary artery lesions in the KD.

Changes in circulating progenitor cells are associated with outcome in heart failure patients: a longitudinal study.

Endothelial progenitor cells as cardiovascular surrogate markers in seropositive rheumatoid arthritis

EPC depletion is inversely correlated with disease activity, RF, and proinflammatory cytokines in seropositive patients, suggesting the pivotal role of inflammation in depletion of EPCs.

Mesenchymal stem cells transplantation improves functions of circulating endothelial progenitor cells in a rat model of pulmonary hypertension

It is suggested that transplantation of MSCs could attenuate MCT induced PH by improving pulmonary vascular repair probably via inhibiting inflammation mediated down-regulation of circulating EPCs.

41 References

CD34+ and Endothelial Progenitor Cells in Patients With Various Degrees of Congestive Heart Failure

CD34+ cells and EPC mobilization occurs in HF and shows a biphasic response, with elevation and depression in the early and advanced phases, respectively, which could be related to the myelosuppressive role of TNF-&agr;.

Circulating inflammatory endothelial cells contribute to endothelial progenitor cell dysfunction in patients with vasculitis and kidney involvement.

IEC significantly inhibited proliferation, migration, and endothelial nitric oxide synthase expression in EPC, suggesting that IEC may contribute to vascular damage by impairing the functional capacity for repair by EPC.

Endothelial dysfunction in patients with rheumatoid arthritis is associated with a reduced number and impaired function of endothelial progenitor cells

Endothelial dysfunction in patients with RA with low grade inflammation is associated with a reduced number and partial dysfunction of EPC, and further studies are needed to explore whether interventions that potentially ameliorate the number and function of E PC also improve endothelial function in these patients.

Elevated circulating tumor necrosis factor-alpha in patients with Kawasaki disease.

The results show that the levels of circulating TNF are increased in acute KD and support the hypothesis that this cytokine may be involved in the pathogenesis of the vascular injury in KD.

Increased Serum Levels of Vascular Endothelial Growth Factor in Kawasaki Disease

The results raise the possibility that VEGF is involved in the pathogenesis of KD, especially in the development of CAL, and further study is needed to clarify the biologic effect of V EGF on coronary arteries in KD.

Circulating Endothelial Progenitor Cells in Patients with ANCA-Associated Vasculitis

Patients with AAV have a significant and persistent deficiency of circulating EPCs, which could reflect an impaired mechanism of vascular repair and may contribute to repeated relapses in these patients.

p38 Mitogen-Activated Protein Kinase Downregulates Endothelial Progenitor Cells

It is demonstrated that p38 MAP kinase plays a pivotal role in the signal transduction pathways regulating the number of EPCs ex vivo and SB203580 can prevent the negative effects of TNF-&agr; and glucose and may be useful to improve the number-of-EPCs for potential cell therapy.

Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension

Circulating EPC numbers are reduced in 2 well-characterized forms of PAH, which also exhibit raised levels of inflammatory mediators and sildenafil treatment may represent a pharmacological means of increasing circulating EPC numbers long-term.

Vascular endothelial damage and repair in antineutrophil cytoplasmic antibody-associated vasculitis.

In patients with AAV, the numbers of circulating CD34+ HPCs and EPCs increased significantly after the institution of immunosuppressive therapy and disease remission, and this finding points to a role of circulatingCD34-derived endothelial progenitor cells in endothelial repair in vasculitis.

Endothelial dysfunction late after Kawasaki disease.

Abnormalities of systemic endothelial function are present many years after resolution of acute Kawasaki disease, even in patients without detectable early coronary artery involvement, and long-term follow-up of all patients with KD is indicated.