The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese

@article{Li2015TheIO,
  title={The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese},
  author={Xiaoliang Li and Jinyu Wei and Ping Xu and Xiang-Qian Yin and Die Hu and Xiao Zhang and Li Liu and Kai Zhang and Changchun Zhou and Tian Wang and Xiaomin Zhang and Meian He and Tangchun Wu and Ming Yang and Huan Guo},
  journal={Molecular Carcinogenesis},
  year={2015},
  volume={54},
  url={https://api.semanticscholar.org/CorpusID:39731}
}
Evidence was shown on interaction between APEX1 148Glu variant and cigarette smoking in increasing lung cancer susceptibility among male Chinese, which may be due to the synergistic effects of APEX2148Glu and PAHs in increasing chromosome damage levels.
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associated with increase lung cancer risk

48 References

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Results suggest that the presence of one or two APE1 Glu allele was associated with the risk of developing lung cancer, and a statistically significant interaction of current smoking status with APE2 Asp148Glu polymorphism was found.

APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese.

The findings suggest that the APEX1 Asp148Glu is associated with increased risk for primary lung cancer in Japanese individuals partaking in smoking.

Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk

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Genetic polymorphisms in ATM, ERCC1, APE1 and iASPP genes and lung cancer risk in a population of southeast China

The results suggest that polymorphism Asn118Asn in ERCC1, A67T in iASPP and Asn148Glu in APE1 may associated with early onset of lung cancer as well as some specific subtype of Lung cancer.

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The functional HSPB1 promoter -1271G>C variant may affect lung cancer susceptibility and survival by modulating endogenous Hsp27 synthesis levels.