A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease…
Hematotoxicity in Workers Exposed to Low Levels of Benzene
Two genetic variants in key metabolizing enzymes, myeloperoxidase and NAD(P)H:quinone oxidoreductase, influenced susceptibility to benzene hematotoxicity and may be particularly evident among genetically susceptible subpopulations.
Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.
Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells
- Luoping Zhang, Xiaojiang Tang, Q. Lan
- Medicine, BiologyCancer Epidemiology, Biomarkers and Prevention
- 1 January 2010
It is suggested that formaldehyde exposure can have an adverse effect on the hematopoietic system and that leukemia induction by formaldehyde is biologically plausible, which heightens concerns about its leukemogenic potential from occupational and environmental exposures.
Modeling Human Metabolism of Benzene Following Occupational and Environmental Exposures
- Sungkyoon Kim, R. Vermeulen, S. Rappaport
- BiologyCancer Epidemiology, Biomarkers and Prevention
- 1 November 2006
Benzene metabolism is highly nonlinear with increasing benzene exposure above 0.03 ppm, and current human toxicokinetic models do not accurately predict benzene metabolism below 3 ppm, which suggests that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers.
Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism.
Metabolite production was investigated among groups of 30 workers aggregated by their benzene exposures and it was found that the urine concentration of each metabolite was consistently elevated when the group's median benzene exposure was at or above the following air concentrations.
Etiologic heterogeneity among non-Hodgkin lymphoma subtypes: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
- L. Morton, S. Slager, J. Sampson
- Medicine, BiologyJournal of the National Cancer Institute…
- 1 August 2014
Using a novel approach to investigate etiologic heterogeneity among NHL subtypes,risk factors that were common among subtypes as well as risk factors that appeared to be distinct among individual or a few subtypes are identified, suggesting both subtype-specific and shared underlying mechanisms.
Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review.
Meta- and pooled analyses of published and unpublished, case-control, genotype-based studies that examined the association between GSTM1 null status and bladder cancer indicate that, among populations studied to date, GSTM 1 null status is associated with a modest increase in the risk of bladder cancer.
Diet and nutrient intakes and risk of non-Hodgkin's lymphoma in Connecticut women.
Risk of NHL associated with diet and nutrient intakes appeared to vary based on NHL subtype, and an association between dietary intake and NHL risk is biologically plausible because diets high in protein and fat may lead to altered immunocompetence, resulting in an increased risk of NHL.
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
It is observed that there is no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.