The angiotensin converting enzyme insertion/deletion polymorphism and intracranial aneurysm: a meta-analysis of case-control studies.
@article{Chen2013TheAC, title={The angiotensin converting enzyme insertion/deletion polymorphism and intracranial aneurysm: a meta-analysis of case-control studies.}, author={Zhixing Chen and Junpeng Ma and Ying Cen and Yi Liu and Chao You}, journal={Neurology India}, year={2013}, volume={61 3}, pages={ 293-9 }, url={https://api.semanticscholar.org/CorpusID:207445078} }
There is a close relationship between ACE I/D polymorphism and IA risk, and it is critical that larger and especially well-designed multicentric studies, which based on interactions of ACE and different confounding factors should be performed to re-evaluate the association.
13 Citations
The association between collagen gene polymorphisms and intracranial aneurysms: a meta-analysis
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Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population
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Genetic basis of intracranial aneurysm formation and rupture: clinical implications in the postgenomic era.
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A thorough understanding of the genetic basis governing risk of IA development and the resultant aneurysmal subarachnoid hemorrhage may aid in screening, clinical management, and risk stratification of these patients, and it may also enable identification of putative mechanisms for future drug development.
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Top level genes that are related to normal vascular physiology, viz. genes of nitric oxide synthesis, endothelial health and smooth muscle biology are demonstrated, thus suggesting involvement of these loci to IS in Chinese patients is suggested.
Molecular basis and genetic predisposition to intracranial aneurysm
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Genome-wide approaches such as DNA linkage and genetic association studies, as well as microarray-based mRNA expression studies, provide unbiased approaches to identify genetic risk factors and dissecting the molecular pathobiology of intracranial aneurysms.
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A thorough review of genome-wide association studies solidifies genetics’ cardinal role in IA, positioning it as a cornerstone resource for professionals in the realms of neurology and genomics.
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There have been measurable improvements in the quality of meta-analyses over recent years, however, several serious deficiencies remain according to the PRISMA statement.
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Medicine
The authors found no evidence of an association between the allelic or genotypic distribution of the ACE I/D polymorphism and aneurysmal subarachnoid hemorrhage or unruptured IAs in a Caucasian population in the US.
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Medicine
The aim of this study was to investigate the association between ACE I/D polymorphism and a risk for aneurysmal SAH in a Polish population and report that the II genotype of ACE gene is a risk factor for the disease.
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Medicine
In this Danish population, ACE haplotypes and the I/D polymorphism did not contribute significantly to the overall risk of intracranial aneurysm rupture and no significant difference in distribution of alleles, genotypes, haplotypes, or haplotype pairs between the 2 populations was found.
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The present study suggests that genetic heterogeneity of the ACE gene may be correlated with the etiology of intracranial aneurysms.
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Medicine
The present results clearly suggest that ethnic origin should be carefully considered in the increasing number of studies on the association between I/D ACE genotype and disease aetiology.
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Medicine
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Medicine
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