Mesenchymal Stem Cell-Based Therapy for Retinal Degenerative Diseases: Experimental Models and Clinical Trials

@article{Holan2021MesenchymalSC,
  title={Mesenchymal Stem Cell-Based Therapy for Retinal Degenerative Diseases: Experimental Models and Clinical Trials},
  author={Vladimir Holan and Kateřina Palack{\'a} and Barbora Heřm{\'a}nkov{\'a}},
  journal={Cells},
  year={2021},
  volume={10},
  url={https://api.semanticscholar.org/CorpusID:232383323}
}
An overview of the therapeutic properties of MSCs, and their use in experimental models of retinal diseases and in clinical trials, is provided.
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178 References

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The interactions among cytokines and other factors in the environment of the diseased retina treated by MSCs are discussed, and results supporting immunoregulatory and trophic roles of molecules secreted in the vicinity of the retina during MSC-based therapy are presented.

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This review summarizes the various properties of MSCs that help to repair and restore the damaged retinal cells and its potential for the treatment of retinal degenerative diseases.

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Progress of mesenchymal stem cell therapy for neural and retinal diseases.

The latest progress of MSC experimental research as well as human clinical trials for neural and retinal diseases, focusing on multiple sclerosis, spinal cord injury, autism, glaucoma, retinitis pigmentosa and age-related macular degeneration are summarized.

The Identification of Interferon-γ as a Key Supportive Factor for Retinal Differentiation of Murine Mesenchymal Stem Cells.

The results show that MSCs can differentiate into cells expressing retinal markers and that this differentiation process is supported by IFN-γ, which is important for retinal regeneration.

Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials

This review will facilitate the understanding of scientists and clinicians of the enormous promise of stem/progenitor cell-based transplantation for RD treatment, and provide incentive for superior employment of such strategies that may be suitable for treatment of other diseases, such as stroke and ischaemia–reperfusion injury.

Stemming retinal regeneration with pluripotent stem cells

Novel stem cell and gene therapy in diabetic retinopathy, age related macular degeneration, and retinitis pigmentosa

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...