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Ocular changes in TgF344-AD rat model of Alzheimer's disease.
- Yuchun Tsai, B. Lu, +6 authors S. Wang
- Investigative ophthalmology & visual science
- 29 January 2014
PURPOSE Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by progressive decline in learning, memory, and executive functions. In addition to cognitive and… Expand
Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases
Cell-based therapeutics offer diverse options for treating retinal degenerative diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). AMD is characterized by both… Expand
Neural Stem Cells Derived by Small Molecules Preserve Vision.
PURPOSE The advances in stem cell biology hold a great potential to treat retinal degeneration. Importantly, specific cell types can be generated efficiently with small molecules and maintained… Expand
Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity
Human umbilical tissue-derived cells (hUTC or palucorcel) are currently under clinical investigation for the treatment of geographic atrophy, a late stage of macular degeneration, but how hUTC… Expand
Multimodal Delivery of Isogenic Mesenchymal Stem Cells Yields Synergistic Protection from Retinal Degeneration and Vision Loss
- B. Bakondi, S. Girman, B. Lu, S. Wang
- Biology, Medicine
- Stem cells translational medicine
- 9 September 2016
We previously demonstrated that subretinal injection (SRI) of isogenic mesenchymal stem cells (MSCs) reduced the severity of retinal degeneration in Royal College of Surgeons rats in a focal manner.… Expand
Light Adaptation Study in RCS Rats, Untreated and with Subretinal Graft of Human RPE Cells
Human iPSC‐Derived Neural Progenitors Preserve Vision in an AMD‐Like Model
Pluripotent stem cell‐derived retinal pigment epithelial (RPE) cells are currently being tested for cell replacement in late‐stage age‐related macular degeneration (AMD). However, preserving vision… Expand
Retinal morphological and functional changes in an animal model of retinitis pigmentosa.
The P23H-1 transgenic rat carries a mutated mouse opsin gene, in addition to endogenous opsin genes, and undergoes progressive photoreceptor loss that is generally characteristic of human autosomal… Expand
A Subsequent Human Neural Progenitor Transplant into the Degenerate Retina Does Not Compromise Initial Graft Survival or Therapeutic Efficacy.
PURPOSE Stem and progenitor cell transplantation provides a promising clinical application for treating degenerative retinal diseases, including age-related macular degeneration (AMD) and retinitis… Expand
Ocular Changes in TgF 344-AD Rat Model of Alzheimer ’ s Disease
Citation: Tsai Y, Lu B, Ljubimov AV, et al. Ocular changes in TgF344-AD rat model of Alzheimer’s disease. Invest Ophthalmol Vis Sci. 2014;55:523– 534. DOI:10.1167/iovs.13-12888 PURPOSE. Alzheimer’s… Expand