Intermittent fasting mitigates cognitive deficits in Alzheimer’s disease via the gut-brain axis

@article{Jia2022IntermittentFM,
  title={Intermittent fasting mitigates cognitive deficits in Alzheimer’s disease via the gut-brain axis},
  author={Mengzhen Jia and Lin Shi and Yihang Zhao and Xinyu Hu and Junhe Zhao and Chen Chen Ding and Yiqiu Shang and Xin Li and Xin Jin and Xiaoshuang Dai and Xuebo Liu and Zhigang Liu},
  journal={bioRxiv},
  year={2022},
  url={https://api.semanticscholar.org/CorpusID:248836002}
}
A 16-week IF regimen significantly improved spatial memory and cognitive function in AD transgenic mice and was accompanied by decreased Aβ accumulation and suppression of neuroinflammation, suggesting new avenues for therapy and nutritional intervention to prevent the development of AD.
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74 References

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It is shown that FMT treatment could improve cognitive deficits and reduce the brain deposition of amyloid-β (Aβ) in APPswe/PS1dE9 transgenic mice and reversed the changes of gut microbiota and SCFAs, and may be a potential therapeutic strategy for AD.

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Alzheimer’s disease and gut microbiota

All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota, and will probably become a new treatment for AD.

The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer's Disease.

Possible mechanisms that could mediate the involvement of gut-brain axis in AD physiopathology are summarized, an integrative model is proposed, and possible role of gut microbiota in modulating neuro-immune functions well beyond the gastrointestinal tract is reviewed.

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The purpose of this review is to summarize and discuss the current findings that may elucidate the role of the gut microbiota in the development of AD and provide new insights into novel therapeutic strategies for AD.

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