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Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies
To conduct a systematic review and meta‐analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs).
The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness.
The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder
It is concluded that CIRS is involved in MDD and BD by regulating the primary immune-inflammatory response, thereby contributing to spontaneous and antidepressant-promoted recovery from the acute phase of illness.
Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies.
- F. Schuch, D. Vancampfort, B. Stubbs
- Medicine, PsychologyAmerican Journal of Psychiatry
- 31 December 2017
OBJECTIVE The authors examined the prospective relationship between physical activity and incident depression and explored potential moderators. METHOD Prospective cohort studies evaluating…
Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis
An updated meta-analysis of studies that measured peripheral levels of cytokines and chemokines during antidepressant treatment in patients with MDD indicates that antidepressants decrease several markers of peripheral inflammation, but does not provide evidence that reductions in peripheral inflammation are associated with antidepressant treatment response.
Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach.
Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: Possible involvement of antioxidant and nitrergic pathways
- A. S. Monte, Greicy Coelho de Souza, D. Macêdo
- Psychology, BiologyJournal of Psychopharmacology
- 17 September 2013
The effects of minocycline and risperidone prevented and reversed ketamine-induced alterations in behavioral paradigms, oxidative markers as well as nitrite levels in the striatum, and suggest that its mechanism of action includes antioxidant and nitrergic systems.
Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta‐analysis
Given the established health benefits of physical activity and its low levels in people with severe mental illness, future interventions specifically targeting the prevention of physical inactivity and sedentary behavior are warranted in this population.
The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature
- A. Carvalho, M. Sharma, A. Brunoni, E. Vieta, G. Fava
- MedicinePsychotherapy and Psychosomatics
- 1 August 2016
The findings of this review should alert the physician to carefully review the appropriateness of AD prescription on an individual basis and to consider alternative treatments if available.
Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies
- K. S. Lai, Celina S. Liu, N. Herrmann
- Medicine, BiologyJournal of Neurology Neurosurgery & Psychiatry
- 9 August 2017
It is suggested that AD is accompanied by a peripheral inflammatory response and that IL-6 may be a useful biological marker to correlate with the severity of cognitive impairment and inversely correlated with mean MMSE scores.