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Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies
To conduct a systematic review and meta‐analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs).
Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large‐scale meta‐analysis of 3,211,768 patients and 113,383,368 controls
TLDR
This large‐scale meta‐analysis confirms that SMI patients have significantly increased risk of CVD and CVD‐related mortality, and that elevated body mass index, antipsychotic use, andCVD screening and management require urgent clinical attention. Expand
Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: Possible involvement of antioxidant and nitrergic pathways
TLDR
The effects of minocycline and risperidone prevented and reversed ketamine-induced alterations in behavioral paradigms, oxidative markers as well as nitrite levels in the striatum, and suggest that its mechanism of action includes antioxidant and nitrergic systems. Expand
Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach.
TLDR
The pathoetiological heterogeneity of MDD/TRD invites the need for mechanistically dissimilar, and empirically validated, treatment approaches for TRD. Expand
Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis
TLDR
An updated meta-analysis of studies that measured peripheral levels of cytokines and chemokines during antidepressant treatment in patients with MDD indicates that antidepressants decrease several markers of peripheral inflammation, but does not provide evidence that reductions in peripheral inflammation are associated with antidepressant treatment response. Expand
Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies.
OBJECTIVE The authors examined the prospective relationship between physical activity and incident depression and explored potential moderators. METHOD Prospective cohort studies evaluatingExpand
Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta‐analysis
TLDR
Given the established health benefits of physical activity and its low levels in people with severe mental illness, future interventions specifically targeting the prevention of physical inactivity and sedentary behavior are warranted in this population. Expand
Repetitive Transcranial Magnetic Stimulation for the Acute Treatment of Major Depressive Episodes: A Systematic Review With Network Meta-analysis
TLDR
The estimated relative ranking of treatments suggested that priming low-frequency and bilateral rT MS might be the most efficacious and acceptable interventions among all rTMS strategies, and the design of larger RCTs investigating the potential of these approaches in the short-term treatment of MDD. Expand
Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration.
TLDR
The results demonstrate that DOXY is comparable to IMI in effectively ameliorate LPS-induced depressive-like behavior, providing a rationale for testing DOXY's antidepressant efficacy in humans. Expand
The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness.
TLDR
This Commission summarises advances in understanding on the topic of physical health in people with mental illness, and presents clear directions for health promotion, clinical care, and future research. Expand
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