Effect of an acute dose of ethanol on lipid peroxidation and on the activity of microsomal glutathione S-transferase in rat liver.

@article{Sippel2009EffectOA,
  title={Effect of an acute dose of ethanol on lipid peroxidation and on the activity of microsomal glutathione S-transferase in rat liver.},
  author={Helmuth Sippel},
  journal={Acta pharmacologica et toxicologica},
  year={2009},
  volume={53 2},
  pages={
          135-40
        },
  url={https://api.semanticscholar.org/CorpusID:21260001}
}
The ethanol-induced inhibition of N-ethylmaleimide-stimulated microsomal glutathione S-transferase activity correlates positively to the concentration of conjugated dienes in the microsome fraction of liver.
View on PubMed
doi.org
18 Citations
Background Citations
1

18 Citations

Effect of ethanol on the microsomal glutathione S-transferase activity in glutathione-depleted rat liver.

Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication

It is indicated that acetaldehyde, like ethanol, stimulates hepatic lipid peroxidation and also selectively affects the hepatic mitochondria.

Combined exposure to m-xylene and ethanol: oxidative stress in the rat liver.

Combined exposure to ethanol and m-xylene led to the increased lipid peroxidation rate in microsomal and lysosomal membranes with a simultaneous decrease in the levels of glutathione sulfhydryls and glutathion-S-transferase activity.

The metabolism of acetaldehyde and not acetaldehyde itself is responsible for in vivo ethanol-induced lipid peroxidation in rats

The effect of chronic ethanol ingestion on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats.

Potentiation of aflatoxin B1 induced hepatotoxicity in male Wistar rats with ethanol pretreatment.

Ethanol pretreatment potentiated AFB1-induced hepatotoxicity by increasing MFO enzymes, aniline hydroxylase and p-nitroanisole-O-demethylases activity and lipid peroxidation, and decreasing in cytochrome b5, epoxide hydrolase activity and hepatic glutathione content.

Effect of acute ethanol administration on the subcellular distribution of iron in rat liver and cerebellum.

Role of xanthine oxidase in ethanol-induced lipid peroxidation in rats.

Vitamin E and glutathione are required for preservation of microsomal glutathione S-transferase from oxidative stress in microsomes.

There was a good correlation between the increased formation of CHCl3 from BrCCl3 in the presence of GSH under anaerobic conditions and the vitamin E level in the microsomes, and GSH prevented the loss of vitamin E and protected the enzyme from attack by free radicals.

Implication of free radical mechanisms in ethanol-induced cellular injury.

31 References

Effect of acute ethanol ingestion on lipoperoxidation and on the activity of the enzymes related to peroxide metabolism in rat liver

Liver lipoperoxidative pressure and glutathione status following acetaldehyde and aliphatic alcohols pretreatments in the rat.

Effect of acute ethanol intoxication on the content of reduced glutathione of the liver in relation to its lipoperoxidative capacity in the rat

Ethanol‐induced hepatotoxicity; experimental observations on the role of lipid peroxidation

It is concluded that lipid peroxidation is unlikely to be an important mechanism in alcohol hepatotoxicity and anti-oxidant compounds which are active in preventing liver injury are discussed.

Drug-induced Lipid Peroxidation in Mouse Liver

It was demonstrated that acute intoxication of mice leads to in vivo formation of lipid peroxides following ethane exhalation of the animals and in vitro determined malondialdehyde correlated fairly well.

No chemical evidence of hepatic lipid peroxidation in acute ethanol toxicity.

Ethanol-induced lipid peroxidation: potentiation by long-term alcohol feeding and attenuation by methionine.

Chronic alcohol feeding potentiates lipid peroxidation produced by an acute dose of ethanol; these changes are not dependent on GSH depression but may be potentiated by it.

Mechanistic aspects of enhanced lipid peroxidation following glutathione depletion in vivo.

Activation of microsomal glutathione S-transferase activity by sulfhydryl reagents.

Lipid peroxidation and the concept of antioxygenic potential: vitamin E changes in acute experimental CCl4-, BrCCl3-, and ethanol-induced liver injury.