• Publications
  • Influence
Cytochrome P-4502E1: its physiological and pathological role.
  • C. Lieber
  • Chemistry, Medicine
    Physiological reviews
  • 1 April 1997
TLDR
2E1 has a unique capacity to activate many xenobiotics to hepatotoxic or carcinogenic products, mainly as a monooxygenase and secondarily via hydroxyl radicals, with transcriptional and posttranscriptional regulation.
High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism.
TLDR
It is concluded that the increased bioavailability of ethanol resulting from decreased gastric oxidation of ethanol may contribute to the enhanced vulnerability of women to acute and chronic complications of alcoholism.
Model of nonalcoholic steatohepatitis.
TLDR
This rat model reproduces the key features of human NASH and provides a realistic experimental model for elucidating its treatment.
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis.
  • C. Lieber
  • Medicine, Biology
    Alcohol
  • 1 August 2004
TLDR
Prevention and therapy opposing the development of steatosis and its progression to more severe injury can be achieved by a multifactorial approach: control of alcohol consumption, avoidance of obesity and of excess dietary long-chain fatty acids, and replenishment of S-adenosylmethionine and PCs by using PPC.
Medical disorders of alcoholism.
  • C. Lieber
  • Medicine
    The New England journal of medicine
  • 19 October 1995
Alcohol is the most frequently abused drug throughout the world. In the United States, it is consumed regularly by about half the adult population, and about 15 to 20 million people are alcoholics.
Ethanol metabolism, cirrhosis and alcoholism.
  • C. Lieber
  • Chemistry, Medicine
    Clinica chimica acta; international journal of…
  • 3 January 1997
TLDR
Polyenylphosphatidylcholine (PPC) fully prevents ethanol-induced septal fibrosis and cirrhosis, opposes ethanol- induced hepatic phospholipid depletion, decreased phosphatidylethanolamine methyltransferase activity and activation of hepatic lipocytes, whereas its dilinoleoyl species increases collagenase activity.
The Discovery of the Microsomal Ethanol Oxidizing System and Its Physiologic and Pathologic Role
  • C. Lieber
  • Chemistry, Medicine
    Drug metabolism reviews
  • 1 January 2004
TLDR
Considering the pathogenic role that up‐regulation of CYP2E1 also plays in alcoholic liver disease, it is apparent that a major therapeutic challenge is now to find a way to control this toxic process.
Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review.
  • C. Lieber
  • Chemistry, Medicine
    Alcoholism, clinical and experimental research
  • 1 June 1999
TLDR
Enhanced ethanol oxidation is associated with cross-induction of the metabolism of other drugs, resulting in drug tolerance, and there is increased conversion of known hepatotoxic agents (such as CCl4) to toxic metabolites, which may explain the enhanced susceptibility of alcoholics to the adverse effects of industrial solvents.
The feeding of alcohol in liquid diets: two decades of applications and 1982 update.
  • C. Lieber, L. Decarli
  • Biology, Medicine
    Alcoholism, clinical and experimental research
  • 1 September 1982
TLDR
Variations of the liquid diet formulation are compared and three standardized basic formulas are being proposed for the rat, suitable for most experimental applications, particularly those intended to mimic the clinical situation in which the various effects of alcohol occur in the setting of liver changes characterized by a fatty liver.
Gender differences in pharmacokinetics of alcohol.
TLDR
The gender difference in alcohol levels is due mainly to a smaller gastric metabolism in females (because of a significantly lesser activity of chi-ADH), rather than to differences in gastric emptying or in hepatic oxidation of ethanol.
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