• Publications
  • Influence
Cytochrome P-4502E1: its physiological and pathological role.
  • C. Lieber
  • Chemistry, Medicine
  • Physiological reviews
  • 1 April 1997
The role of the microsomal ethanol-oxidizing system (MEOS) in hepatic ethanol metabolism is reviewed, with focus on its constitutive, ethanol-inducible cytochrome P-4502E1 (2E1). The MEOS wasExpand
  • 822
  • 33
High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism.
After consuming comparable amounts of ethanol, women have higher blood ethanol concentrations than men, even with allowance for differences in size, and are more susceptible to alcoholic liverExpand
  • 1,065
  • 29
Model of nonalcoholic steatohepatitis.
BACKGROUND Obesity and diabetes are frequently associated with nonalcoholic steatohepatitis (NASH), but studies have been hampered by the absence of a suitable experimental model. OBJECTIVE OurExpand
  • 373
  • 29
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis.
  • C. Lieber
  • Medicine, Biology
  • Alcohol
  • 1 August 2004
Liver disease in the alcoholic is due not only to malnutrition but also to ethanol's hepatotoxicity linked to its metabolism by means of the alcohol dehydrogenase and cytochrome P450 2E1 (CYP2E1)Expand
  • 526
  • 27
The feeding of alcohol in liquid diets: two decades of applications and 1982 update.
  • C. Lieber, L. Decarli
  • Biology, Medicine
  • Alcoholism, clinical and experimental research
  • 1 September 1982
The technique of feeding ethanol as part of a totally liquid diet was invented two decades ago and its successful application for the intervening period is reviewed. This technique results in muchExpand
  • 650
  • 20
Medical disorders of alcoholism.
  • C. Lieber
  • Medicine
  • The New England journal of medicine
  • 19 October 1995
Alcohol is the most frequently abused drug throughout the world. In the United States, it is consumed regularly by about half the adult population, and about 15 to 20 million people are alcoholics.Expand
  • 404
  • 20
Ethanol metabolism, cirrhosis and alcoholism.
  • C. Lieber
  • Chemistry, Medicine
  • Clinica chimica acta; international journal of…
  • 3 January 1997
Alcohol-induced tissue damage results from associated nutritional deficiencies as well as some direct toxic effects, which have now been linked to the metabolism of ethanol. The main pathway involvesExpand
  • 396
  • 20
The Discovery of the Microsomal Ethanol Oxidizing System and Its Physiologic and Pathologic Role
  • C. Lieber
  • Chemistry, Medicine
  • Drug metabolism reviews
  • 1 January 2004
Oxidation of ethanol via alcohol dehydrogenase (ADH) explains various metabolic effects of ethanol but does not account for the tolerance. This fact, as well as the discovery of the proliferation ofExpand
  • 214
  • 19
Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review.
  • C. Lieber
  • Chemistry, Medicine
  • Alcoholism, clinical and experimental research
  • 1 June 1999
Oxidation of ethanol via alcohol dehydrogenase (ADH) explains various metabolic effects of ethanol but does not account for the tolerance and a number of associated disorders that develop in theExpand
  • 400
  • 18
Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome.
Acute ethanol administration (3 g/kg twice a day) to pregnant mice, from the 9th thru the 11th day of gestation, resulted in hypomethylation of fetal deoxyribonucleic acid (DNA). Nuclei isolated fromExpand
  • 249
  • 17