Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study

@article{Liu2019DocosapentaenoicAA,
  title={Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study},
  author={Jiaqing Liu and Huaqiang Zhou and Yaxiong Zhang and Yan Huang and Wenfeng Fang and Yunpeng Yang and Shaodong Hong and Gang Chen and Shen Zhao and Xi Chen and Zhonghan Zhang and Jiayi Shen and Wei Xian and Jian-hua Zhan and Yuanyuan Zhao and Xue Hou and Yuxiang Ma and Ting Zhou and Hongyun Zhao and Li Zhang},
  journal={Cancer Medicine},
  year={2019},
  volume={8},
  pages={1817 - 1825},
  url={https://api.semanticscholar.org/CorpusID:73444546}
}
This study investigates the causal effect of DPA on lung cancer with Mendelian randomization method and finds that it is unclear whether docosapentaenoic acid, a kind of polyunsaturated fatty acid, is linked to the risk of lung cancer.

Polyunsaturated Fatty Acid Levels and the Risk of Keratinocyte Cancer: A Mendelian Randomization Analysis

Higher genetically predicted levels of linoleic acid and alpha-linolenic acid were associated with a reduced BCC risk, but arachidonic acid and eicosapentaenoic acid was associated with an increased BCC risk and PUFA-related diet and supplementation could influence BCC etiology.

A modifiable risk factors atlas of lung cancer: A Mendelian randomization study

A modifiable risk factors atlas of lung cancer is constructed by using the two‐sample Mendelian randomization framework to assess the causal effects of putative modifiablerisk factors on lung cancer.

Polyunsaturated fatty acid levels and the risk of keratinocyte cancer: A Mendelian Randomisation analysis.

Higher genetically predicted levels of linoleic acid and alpha-linolenic acid were associated with a reduced BCC risk, but arachidonic acid and eicosapentaenoic acid had a higher BCC risk.

Causal Effects of N-6 Polyunsaturated Fatty Acids on Age-related Macular Degeneration: A Mendelian Randomization Study.

This study provided genetic evidence that circulating LA accounted for protective effects of n-6 PUFAs against the risk of AMD, whereas AA was responsible for deleterious effects on higher AMD risk.

Circulating polyunsaturated fatty acids and COVID-19: a prospective cohort study and Mendelian randomization analysis

It is supported that higher circulating PUFAs, either omega-3 or omega-6, are protective against severe COVID-19, while Omega-3 PUFas, especially DHA, were also associated with reducing CO VID-19 susceptibility.

A Causal Relationship between Vitamin C Intake with Hyperglycemia and Metabolic Syndrome Risk: A Two-Sample Mendelian Randomization Study

In conclusion, insufficient dietary VC intake potentially increased the MetS and hyperglycemia risk in Asian adults and low VC intake can contribute to increasing type 2 diabetes incidence in Asians.

Plasma metabolites and risk of seven cancers: a two-sample Mendelian randomization study among European descendants

This study unveils plausible causal relationships between 66 distinct plasma metabolites and cancer risk, expanding the understanding of the role of circulating metabolites in cancer genetics and etiology.

Non-Specific Elevated Serum Free Fatty Acids in Lung Cancer Patients: Nutritional or Pathological?

Levels of serum free fatty acids were significantly higher in lung cancer patients compared to those in healthy controls, indicating the involvement of the fatty acids in the tumor metabolism.

The Causal Effect of Gut Microbiota and Plasma Metabolome on Lung Cancer and the Heterogeneity across Subtypes: A Mendelian Randomization Study

This study highlighted the heterogeneity of the gut microbiome and plasma metabolome in a lung cancer subtype and elucidated the potential underlying mechanisms, which could pave the way for more personalized lung cancer prevention and treatment.

Systematic review of Mendelian randomization studies on risk of cancer

Despite the large amount of research on genetically predicted risk factors for cancer risk, limited associations are supported by robust evidence for causality and future research should focus on more thorough assessment of sensitivity MR analyses and on more transparent reporting.

Polyunsaturated fatty acids and risk of melanoma: A Mendelian randomisation analysis

The MR analysis suggests that the effect of PUFA levels on melanoma risk is either zero or very small, and the inverse variance weighted method to estimate a causal odds ratio is used.

Polyunsaturated Fatty Acid Intake and Risk of Lung Cancer: A Meta-Analysis of Prospective Studies

The evidence regarding the relationship between polyunsaturated fatty acid (PUFA) intake and risk of lung cancer is summarized using a dose response meta-analytic approach to indicate that PUFA intake had little or no effect on lung cancer risk.

A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk

The association of specific types of dietary PUFA intakes and lung cancer risk in two population‐based cohort studies with a total of 121,970 study participants is evaluated, highlighting an important public health impact ofPUFA intakes toward intervention/prevention programs of lung cancer.

Dietary PUFA and cancer

Challenges in utilising FA in cancer modulation exist regarding intake and effect on cell structure and biochemical interactions within the cell in the prevention of cancer development, so utilising dietary PUFA in a specific n-6:n-3 ratio may be an important chemopreventive tool in altering the growth characteristics of cancer cells.

Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium

Results from this study suggest that circulating ω-3 and ψ-6 PUFAs may have a different role in the aetiology of early- and late-onset prostate cancer.

Marine polyunsaturated fatty acids and cancer therapy

Although a range of doses have been trialled, it would appear that supplementation of fish oil or EPA/DHA is associated with positive clinical outcomes, and further research is still required to determine the mechanisms via which marine PUFAs are mediating their effects.

Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study

The data confirm that the continual assumption of EPA plus DHA determined an anti-inflammatory and anti-oxidative action which could be considered a preliminary goal in anti-cachectic therapy.

Fish Consumption and Lung Cancer Risk: Systematic Review and Meta-Analysis

This study identifies a significant association between fish consumption and lung cancer, confirming a protective role of fish in lung cancer.

Metabolome-wide association study identified the association between a circulating polyunsaturated fatty acids variant rs174548 and lung cancer

The findings provide a diet-related risk factor and may have important implications for prevention on lung cancer and proposed that plasma PUFAs could be causally associated with lung cancer based on the idea of mendelian randomization.
...