X. Shu

Publications1,232
h-index117
Citations62,305
Highly Influential Citations2,510
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Association between body-mass index and risk of death in more than 1 million Asians.
TLDR
Underweight was associated with a substantially increased risk of death in all Asian populations, however, the excess risk of died was seen among East Asians but not among Indians and Bangladeshis.
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Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women.
TLDR
High intake of foods with a high glycemic index and glycemic load, especially rice, the main carbohydrate-contributing food in this population, may increase the risk of type 2 diabetes mellitus in Chinese women.
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A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
TLDR
A genome-wide association study of gastric cancer and esophageal squamous cell carcinoma in ethnic Chinese subjects in which 551,152 SNPs were genotyped could provide insight into the high incidence of both cancers in China.
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Genome-wide association study identifies a novel breast cancer susceptibility locus at 6q25.1
We carried out a genome-wide association study among Chinese women to identify risk variants for breast cancer. After analyzing 607,728 SNPs in 1,505 cases and 1,522 controls, we selected 29 SNPs for…
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Association analysis identifies 65 new breast cancer risk loci
TLDR
A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
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Large-scale genotyping identifies 41 new loci associated with breast cancer risk
TLDR
A meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, and identified 29,807 SNPs for further genotyping suggests that more than 1,000 additional loci are involved in breast cancer susceptibility.
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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
TLDR
The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.
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Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women.
  • X. Shu, F. Jin, W. Zheng
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a…
  • 1 May 2001
TLDR
It is suggested that high soy intake during adolescence may reduce the risk of breast cancer in later life.
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Alcohol, tobacco and breast cancer – collaborative reanalysis of individual data from 53 epidemiological studies, including 58 515 women with breast cancer and 95 067 women without the disease
TLDR
In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis.
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Meta-analysis identifies common variants associated with body mass index in East Asians
TLDR
A meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians and three additional loci nearly reached the genome-wide significance threshold may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.
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