AHNAK Contributes to Hepatocellular Carcinoma Growth by Interacting with IGF-1R
- Kang LiKe Song Yonghong Zhang
- 1 December 2022
Medicine, Biology
Results suggested that the AHNAK complex contributes to HCC growth, potentially by interacting with IGF-1R, which partially reflected the signature of HCC field cancerization.
Exploring the Hepatotoxicity of Drugs through Machine Learning and Network Toxicological Methods
- Yonghong ZhangTiantian Tang Lingyun Mo
- 16 March 2023
Medicine, Computer Science
A novel method based on network strategies and machine learning algorithms successfully explored the DILI of drugs and developed novel descriptors according to the number of drug genes with different network overlapped distance parameters for the hepatotoxicity of drugs.
Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB
- Hong WangXin SunF. GaoBiao ZhongYonghong ZhangZhijun Sun
- 5 January 2012
Medicine
UTI inhibits the proliferation of human breast cancer cells and the growth of xenografted tumors, induces cancer cell apoptosis, and enhances the anti-tumor effect of TXT.
Identification of potential therapeutic targets and mechanisms of COVID-19 through network analysis and screening of chemicals and herbal ingredients
- Hong WangJingqing Zhang Yonghong Zhang
- 9 September 2021
Medicine, Chemistry
Briefings Bioinform.
It is found that different drugs may play different roles in the process of virus invasion and the onset and development of the COVID-19 disease, and the method has an undeniable immense advantage in the feasibility analysis of drug repurposing or drug screening, especially in the analysis of herbal ingredients.
Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB
- Hong WangXin-chen SunF. GaoBiao ZhongYonghong ZhangZhijun Sun
- 5 January 2012
Medicine
The gene expression and protein expression of IGF-1R, PDGFA, NGF, NF-κB and JNk-2 in breast cancer cells was inhibited by UTI and TXT, and the anti-tumor effect of TXT was enhanced.