Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes
The genome of a new SIVcpz strain is sequenced and the subspecies identity of all known SIV cpz-infected chimpanzees is determined, by mitochondrial DNA analysis, and it is found that two chimpanzee subspecies in Africa harbour SIVCPz and that their respective viruses form two highly divergent (but subspecies-specific) phylogenetic lineages.
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
In isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs.
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
- Yansheng Du, Zhi-zhong Ma, S. Paul
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 27 November 2001
The results suggest that minocycline blocks MPTP neurotoxicity in vivo by indirectly inhibiting MPTP/MPP+-induced glial iNOS expression and/or directly inhibiting NO-induced neurotoxicity, most likely by inhibiting the phosphorylation of p38 MAPK.
DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements
DEG 10 includes essential genomic elements under different conditions in three domains of life, with customizable BLAST tools.
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
The newly emergent Middle East respiratory syndrome coronavirus (MERS-CoV) can cause severe pulmonary disease in humans, representing the second example of a highly pathogenic coronavirus, the first…
Microbial biodegradation of polyaromatic hydrocarbons.
The goal of this review is to provide an outline of the current knowledge of microbial PAH catabolism to facilitate the development of new methods to enhance the bioremediation of PAH-contaminated sites.
A simple and effective method for filling gaps in Landsat ETM+ SLC-off images
Ferroptosis as a target for protection against cardiomyopathy
- X. Fang, Hao Wang, Fudi Wang
- Biology, MedicineProceedings of the National Academy of Sciences
- 28 January 2019
It is discovered and demonstrated that ferroptosis, a programmed iron-dependent cell death, as a mechanism in murine models of doxorubicin (DOX)- and ischemia/reperfusion (I/R)-induced cardiomyopathy and Mitochondria-targeted antioxidant MitoTEMPO significantly rescued DOX cardiopathy, supporting oxidative damage of mitochondria as a major mechanism in ferroPTosis-induced heart damage.
Phenotypic properties of transmitted founder HIV-1
TF viruses are enriched for higher Env content, enhanced cell-free infectivity, improved dendritic cell interaction, and relative IFN-α resistance, which should be considered in the development and testing of AIDS vaccines.
Human infection by genetically diverse SIVSM-related HIV-2 in West Africa
It is indicated that HIV-2, SIVSM and SIVMAC comprise a single, highly diverse group of lentiviruses which cannot be separated into distinct phylogenetic lineages according to species of origin.