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Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes
TLDR
The genome of a new SIVcpz strain is sequenced and the subspecies identity of all known SIV cpz-infected chimpanzees is determined, by mitochondrial DNA analysis, and it is found that two chimpanzee subspecies in Africa harbour SIVCPz and that their respective viruses form two highly divergent (but subspecies-specific) phylogenetic lineages. Expand
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
The newly emergent Middle East respiratory syndrome coronavirus (MERS-CoV) can cause severe pulmonary disease in humans, representing the second example of a highly pathogenic coronavirus, the firstExpand
DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements
TLDR
DEG 10 includes essential genomic elements under different conditions in three domains of life, with customizable BLAST tools. Expand
Microbial biodegradation of polyaromatic hydrocarbons.
TLDR
The goal of this review is to provide an outline of the current knowledge of microbial PAH catabolism to facilitate the development of new methods to enhance the bioremediation of PAH-contaminated sites. Expand
Human infection by genetically diverse SIVSM-related HIV-2 in West Africa
TLDR
It is indicated that HIV-2, SIVSM and SIVMAC comprise a single, highly diverse group of lentiviruses which cannot be separated into distinct phylogenetic lineages according to species of origin. Expand
Diversity Considerations in HIV-1 Vaccine Selection
TLDR
Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half. Expand
Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial Ischemia-Reperfusion: The Roles of PI3-Kinase, Akt, and Endothelial Nitric Oxide Synthase Phosphorylation
TLDR
In vivo administration of insulin activated Akt through the PI3-kinase–dependent mechanism and reduced postischemic myocardial apoptotic death and contributed significantly to the antiapoptotic effect of insulin. Expand
Phenotypic properties of transmitted founder HIV-1
  • N. Parrish, F. Gao, +29 authors B. Hahn
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 29 March 2013
TLDR
TF viruses are enriched for higher Env content, enhanced cell-free infectivity, improved dendritic cell interaction, and relative IFN-α resistance, which should be considered in the development and testing of AIDS vaccines. Expand
Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells.
TLDR
Flow cytometric analysis showed that SiO(2) nanoparticles can cause G2/M phase arrest and apoptotic sub-G1 population increase in a dose-dependent manner, and exposure to SiO-2 nanoparticles resulted in a doses-dependent cytotoxicity in cultured HEK293 cells that was associated with increased oxidative stress. Expand
Genome-wide analysis of the AP2/ERF gene family in Populus trichocarpa.
TLDR
The number genes of total AP2/ERF family genes, DREB subfamily, and ERF subfamily from Populus trichocarpa were about 1.4-1.6-fold more than those from A. thaliana, and the rates were very similar for the putative homologs between Populus and Arabidopsis. Expand
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