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Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma

6-OAP is a new cell cycle inhibitor which shows therapeutic potentials for Multiple myeloma and exhibited potent anti-MM activity in nude mice and favorable pharmacokinetics in rats.
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Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor

6-OAP inhibited tumor growth in SCID mice intravenously injected with lung cancer cells, and downregulated both STAT3 and Skp2 in tumor samples, suggesting that this compound may target Skp1 and STAT3 to suppress Skp 2, augmenting its anti-lung cancer activity.
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Protection against chemotherapy- and radiotherapy-induced side effects: A review based on the mechanisms and therapeutic opportunities of phytochemicals.

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Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway

The mechanism of C. minima and its active components in the amelioration of oxidative stress, which holds the promise for the treatment of neurodegenerative disease is examined.
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HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration

The data establish a regulatory feedback loop of TGF-β signaling, wherein HDAC8 as a novel cofactor of SMAD3/4 complex, transcriptionally suppresses SIRT7 via local chromatin remodeling and thus further activates TGF -β signaling.
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6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo

It is demonstrated that 6-OAP exerts antineuroinflammatory effects and can be considered a novel drug candidate for the treatment of neuroinflammatory diseases.
Springer (opens in a new tab)

6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo

It is demonstrated that 6-OAP exerts antineuroinflammatory effects and can be considered a novel drug candidate for the treatment of neuroinflammatory diseases.
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Petchiether A attenuates obstructive nephropathy by suppressing TGF‐β/Smad3 and NF‐κB signalling

The findings suggest that petA protects against renal inflammation and fibrosis by selectively inhibiting TGF‐β/Smad3 signalling.
Wiley (opens in a new tab)

Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells

The mechanism of 6-OAP cytotoxicity in all cell lines was associated with the induction of apoptosis with the presence of cleaved caspase-3 and PARP, and these observations are likely to provide a framework for future studies of 6/OAP therapy in MM.
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A small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer

D6 mimics a natural product isolated from the roots of Codonopsis pilosula and selectively competes with T790M-EGFR-AM to bind to HSP90, thus facilitating the ubiquitination dependent proteasomal degradation of T790m-EG FR-AM, and shows efficacy in overcoming EGFR-TKIs-resistance in NSCLCs.
Springer (opens in a new tab)
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