Isomerization of a single aspartyl residue of anti-epidermal growth factor receptor immunoglobulin gamma2 antibody highlights the role avidity plays in antibody activity.
- Douglas S RehderD. Chelius P. Bondarenko
- 31 January 2008
Medicine, Chemistry
The data indicate that antibodies containing either one or two isomerized residues were not effective in inhibiting EGFR-mediated cell proliferation, and that two unmodified antigen binding regions were needed to achieve full efficacy.
The LC/MS analysis of glycation of IgG molecules in sucrose containing formulations.
- H. GadgilP. Bondarenko M. Treuheit
- 1 October 2007
Chemistry, Medicine
Glycation of a recombinant monoclonal IgG2 molecule, in sucrose containing liquid formulations, was studied using reversed-phase LC/MS analysis of the intact IgG, the F(ab')2 fragments and after…
Metal donation and apo-metalloenzyme activation by stable isotopically labeled metallothionein.
- A. MasonN. PericoR. MoellerKelly ThrippletonT. PotterD. Lloyd
- 1 August 2004
Chemistry
PLATELET ACTIVATING FACTOR (PAF) AS A MEDIATOR OF PROTEINURIA IN ISOLATED PERFUSED KIDNEY (IPK).
- F. DelaniM. TagliaferriD. MacconiC. LupiniN. PericoG. Rumuzzi
- 1987
Medicine, Biology
The data indicate that PAF may directly increase glomerular permeability to proteins and cause proteinuria stimulating platelet and neutrophil cationic protein release in glomerulonephritis.
Conformational implications of an inversed pH-dependent antibody aggregation.
- N. PericoJ. PurtellT. DillonM. Ricci
- 1 September 2009
Chemistry, Medicine
The temperature-dependence of clipping suggested that clip-mediated aggregation was responsible for the increased higher order aggregates at low pH and elevated temperatures and have implications on the mechanisms of antibody aggregation and on the validity of accelerated data to predict shelf-life accurately.