Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
- Jagath R JunutulaH. Raab W. Mallet
- 1 August 2008
Medicine, Chemistry
The favorable in vivo properties of the near-homogenous composition of this conjugate suggest that the strategy offers a general approach to retaining the antitumor efficacy of antibody-drug conjugates, while minimizing their systemic toxicity.
Site-specific conjugation of cytotoxic drugs to antibodies substantially improves the therapeutic window
- Jagath R JunutulaH. Raab R. Scheller
- 2008
Medicine, Chemistry
Jagath R Junutula, Helga Raab, Suzanna Clark, Sunil Bhakta, Douglas D Leipold, Sylvia Weir, Yvonne Chen, Michelle Simpson, Siao Ping Tsai, Mark S Dennis, Yanmei Lu and William Mallet are among the authors of this book.
097 Evidence of a female-specific causal relationship between endogenous testosterone levels and acne
- R. RispoliR. Ramessur M. Simpson
- 1 December 2022
Medicine, Biology
048 The anti-drug antibody response is associated with amino acid variation within the HLADRB1 peptide-binding groove
- T. TsakokB. S. GroupP. ConsortiumC. SmithM. Simpson
- 1 October 2021
Medicine