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Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review)

It is proposed here that the thromboembolic events and eventually the development of DIC provoked by SARS-CoV-2 infection may represent a secondary anti-phospholipid antibody syndrome (APS), and it will be proved that secondary APS is likely responsible for coagulopathy during the course of COVID-19 infection.
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Evaluation of olfactory dysfunction in neurodegenerative diseases.

The aim of this review is to summarize the major neurological diseases which are preceded or accompanied by olfactory dysfunction, and new instrumental approaches, such as psychophysical testing, OERPs and fMRI, might to be good candidates to become useful additional tools in clinical protocols for early diagnosis of neurological diseases.
PubMed (opens in a new tab)

Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies

A specific set of biological pathways altered in primary human lung epithelium upon SARS-CoV-2 infection is identified, and a comparison with SARS-CoV from the 2003 pandemic was studied, and potential drugs to control disease progression are predicted.
PubMed (opens in a new tab)

Magnetic resonance imaging markers for early diagnosis of Parkinson's disease☆

Conventional magnetic resonance imaging (MRI) and advanced MRI techniques are useful to differentiate early PD with initial motor symptoms from atypical parkinsonian disorders, thus, making easier early diagnosis.
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Cognitive Decline in Rheumatoid Arthritis: Insight into the Molecular Pathogenetic Mechanisms

The emerging body of data suggests that clinical, psychological, and biological factors may contribute to the pathogenesis of cognitive decline in RA, including cardiovascular complications, chronic pain, depression, inflammatory factors, changes in hormone levels, drug side effects, and genetics.
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Pharmacotherapy for Disorders of Consciousness: Are ‘Awakening’ Drugs Really a Possibility?

The possible mechanisms by which these drugs may exert their effects in promoting recovery of consciousness are discussed, highlighting how many findings are often the result of sporadic events rather than prospective controlled trials or implementation of standard treatment guidelines.
Springer Nature (opens in a new tab)

Comprehensive Analysis of RNA-Seq Gene Expression Profiling of Brain Transcriptomes Reveals Novel Genes, Regulators, and Pathways in Autism Spectrum Disorder

Novel core genes and molecular signatures involved with ASD were identified by the meta-analysis of gene expression signatures of brain cortex of ASD patients using two publicly available RNA-seq studies.
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Anxiety, depression, and quality of life in Parkinson’s disease: the implications of multidisciplinary treatment

The multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood, motor abilities, autonomy in the activities of daily life, perception of quality of life, cognitive performance and speech skills.
Wolters Kluwer (opens in a new tab)

Role of statins in the treatment of multiple sclerosis.

Large, prospective, randomized, double-blind, placebo-controlled trials, designed to evaluate the long-term effects of statins alone or in add-on to other disease-modifying therapies, are needed to support their routine clinical use in multiple sclerosis.
PubMed (opens in a new tab)

Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.

In continuation of our studies, we here report a series of non-carboxylic acid containing 2,4-thiazolidinedione derivatives, analogues of previously synthesized carboxylic acids which we had found to…
PubMed (opens in a new tab)
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