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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

These studies uncover diverse substrate receptors for Cul4 and identify Cdt2 as a conserved component of the Cul4-Ddb1 E3 that is essential to destroy Cdt1 and ensure proper cell cycle regulation of DNA replication.
PubMed (opens in a new tab)

The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

The data demonstrate that Keap1 restrains Nrf2 activity via its capacity to target NRF2 to a cytoplasmic Cul3-based E3 ligase and suggest a model in which Keap 1 coordinately regulates both Nrf 2 accumulation and access to target genes.
ASMUSA (opens in a new tab)

Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

This work identifies a divergent E1 in vertebrates and sea urchin, Uba6, which specifically activates ubiquitin but not other UBLs in vitro and in vivo, and reveals unexpected complexity in the pathways that control the conjugation of Ubiquitin.
Nature (opens in a new tab)

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

A requirement for SCFbeta-TRCP in Cdc25A turnover during an unperturbed cell cycle and in response to DNA damage is demonstrated and roles for an additional kinase(s) in Chk1-dependent Cdc 25A turnover are suggested.
PubMed (opens in a new tab)

Systematic analysis and nomenclature of mammalian F-box proteins.

The current expectation is that all cullin-containing ligases will share the modular nature of the original SCF family of ligases, which form a superfamily of modular E3s that use cullin proteins as a scaffold.
PubMed (opens in a new tab)

microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder

This study is the first to find altered miRNA profiles in postmortem prefrontal cortex from schizophrenia patients, and distinguished eight miRNAs distinguished by being expressed at lower microarray levels in schizophrenia samples versus comparison samples with quantitative RT-PCR.
Springer Nature (opens in a new tab)

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.

It is reported here that phosphorylation of c-Jun by GSK3 creates a high-affinity binding site for the E3 ligase Fbw7, which targets c- Jun for polyubiquitination and proteasomal degradation.
PubMed (opens in a new tab)

The human and mouse replication-dependent histone genes.

The multigene family encoding the five classes of replication-dependent histones has been identified from the human and mouse genome sequence, and the complexity of the histone protein complement significantly greater than previously thought.
PubMed (opens in a new tab)

Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

The results suggest that Fbw7 may be a major regulator of lipid metabolism through control of the phosphorylation-dependent degradation of the SREBP family of transcription factors.
PubMed (opens in a new tab)

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

PRP19 mutants that cannot bind RPA or function as an E3 ligase failed to support the ATR response, revealing that PRP19 drives ATR activation by acting as an RPA-ssDNA-sensing ubiquitin ligase during the DDR.
PubMed (opens in a new tab)
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