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Formyl-peptide receptors revisited.

This work has shown that the formyl-peptide receptor and its variant FPRL1 (FPR-like 1) are involved in host defense against bacterial infection and in the clearance of damaged cells, and suggests that these receptors contribute to disease pathogenesis and host defense.
PubMed (opens in a new tab)

Pleiotropic roles of formyl peptide receptors.

These new findings have greatly expanded the functional scope of the formyl peptide receptors and call for more in-depth investigation of the role of these receptors in pathophysiological conditions.
PubMed (opens in a new tab)

Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation.

This study suggests that FPR and FPRL1 in phagocytes react to a broad spectrum of agonists and WKYMVm as a remarkably potent agonist provides a valuable tool for studying leukocyte signaling via these receptors.
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Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1.

It is shown that the 42 amino acid form of beta amyloid peptide, Abeta(42), is a chemotactic agonist for a seven-transmembrane, G-protein-coupled receptor named FPR-Like-1 (FPRL1), which is expressed on human mononuclear phagocytes, which may mediate inflammation seen in AD.
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Humanin, a Newly Identified Neuroprotective Factor, Uses the G Protein-Coupled Formylpeptide Receptor-Like-1 as a Functional Receptor1

Humanin shares human FPRL1 and mouse FPR2 with Aβ42 and it is suggested that Humanin may exert its neuroprotective effects by competitively inhibiting the access of F PRL1 to A β42.
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Chemokines and chemokine receptors: their manifold roles in homeostasis and disease.

Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites…
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Amyloid β42 Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1

It is shown that the 42 amino acid form of b amyloid peptide, Ab42, is a chemotactic agonist for a seven-transmembrane, G-protein-coupled receptor named FPR-Like-1 (FPRL1), which is expressed on human mononuclear phagocytes, which may mediate inflammation seen in AD.
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Differential Regulation of Formyl Peptide Receptor-Like 1 Expression During the Differentiation of Monocytes to Dendritic Cells and Macrophages1

It is shown that FPRL1 is down-regulated as monocytes differentiate into DC, which suggests that this chemotactic receptor may be more involved in inflammatory reactions and innate host defense than in adaptive immune responses.
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Receptors for chemotactic formyl peptides as pharmacological targets.

By interacting with a variety of exogenous and host-derived agonists, formyl peptide receptors may play important roles in proinflammatory and immunological diseases and constitute a novel group of pharmacological targets.
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The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1.

It is shown that PrP(106-126) is chemotactic for human monocytes through the use of a G protein-coupled receptor formyl peptide receptor-like 1 (FPRL1), which has been reported to interact with a diverse array of exogenous or endogenous ligands.
PubMed (opens in a new tab)
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