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- Publications
- Influence
Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes,…
- De Yang, Q. Chen, +5 authors O. Chertov
- Biology, Medicine
- The Journal of experimental medicine
- 2 October 2000
We have previously shown that antimicrobial peptides like defensins have the capacity to mobilize leukocytes in host defense. LL-37 is the cleaved antimicrobial 37-residue, COOH-terminal peptide of… Expand
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
- D. Yang, O. Chertov, +8 authors J. Oppenheim
- Biology, Medicine
- Science
- 15 October 1999
Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory… Expand
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family
Formyl peptide receptors (FPRs) are a small group of seven-transmembrane domain, G protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and are known to be important… Expand
Formyl-peptide receptors revisited.
Leukocytes accumulate at sites of inflammation and microbial infection in direct response to locally produced chemotactic factors, which signal through specific G protein-coupled receptors. The first… Expand
Pleiotropic roles of formyl peptide receptors.
- Y. Le, J. Oppenheim, J. Wang
- Biology, Medicine
- Cytokine & growth factor reviews
- 1 March 2001
FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides, these… Expand
A Seven-transmembrane, G Protein–coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells
- S. Su, W. Gong, +4 authors J. Wang
- Biology, Medicine
- The Journal of experimental medicine
- 18 January 1999
We have previously reported (Badolato, R., J.M. Wang, W.J. Murphy, A.R. Lloyd, D.F. Michiel, L.L. Bausserman, D.J. Kelvin, and J.J. Oppenheim. 1994. J. Exp. Med. 180:203; Xu, L., R. Badolato, W.J.… Expand
Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1.
Amyloid beta (Abeta) is a major contributor to the pathogenesis of Alzheimer's disease (AD). Although Abeta has been reported to be directly neurotoxic, it also causes indirect neuronal damage by… Expand
Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils (*)
- O. Chertov, D. Michiel, +6 authors J. Oppenheim
- Biology, Medicine
- The Journal of Biological Chemistry
- 9 February 1996
Reports that interleukin-8 (IL-8) induces the infiltration of neutrophils followed by T-cells into injection sites led us to postulate that by stimulation of neutrophil degranulation IL-8 may cause… Expand
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.
- P. Epling-Burnette, J. Liu, +9 authors T. Loughran
- Biology, Medicine
- The Journal of clinical investigation
- 1 February 2001
Large granular lymphocyte (LGL) leukemia is characterized by the expansion of antigen-activated cytotoxic T lymphocytes. These leukemic cells are resistant to Fas-mediated apoptosis despite… Expand
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo
- Tim Lämmermann, P. Afonso, +4 authors R. Germain
- Biology, Medicine
- Nature
- 26 May 2013
Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the… Expand
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