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Direct comparison of 18F-FDG and 11C-methionine PET in suspected recurrence of glioma: sensitivity, inter-observer variability and prognostic value

FDG and MET PET studies provide complementary prognostic information in patients with suspected brain tumour recurrence or progression after primary therapy, and MET is considered the single agent of choice in the evaluation of these patients because of its sensitivity and clearer delineation of the suspected recurrence.
Springer Nature (opens in a new tab)

In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232

Application of [11C]MK-4232 in human PET studies revealed that telcagepant achieved only low receptor occupancy at an efficacious dose (140 mg PO), therefore, it is unlikely that antagonism of central CGRP-R is required for migraine efficacy.
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Non-invasive grading of brain tumours using dynamic amino acid PET imaging : does it work for 11C-Methionine?

FET–PET should be advocated over MET–PET as its uptake mechanism also allows noninvasive grading in glioma and literature data indicate that both tracers have a similar performance regarding biopsy location, tumour delineation, and detection of recurrence.
Springer Nature (opens in a new tab)

[11C]methionine PET, histopathology, and survival in primary brain tumors and recurrence.

There is no significant prognostic value in studying maximal methionine UI in brain tumors, and the clinical use of MET should be primarily focused on questions such as detection of recurrence, biopsy guidance, and radiation therapy target volume delineation.
PubMed (opens in a new tab)

Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging.

In all neocortical regions studied, [18F]altanserin uptake correlates negatively with age, and the reduction in cerebral 5-HT2A receptor binding thus directly reflects the loss of specific 5- HT2A receptors with age.
PubMed (opens in a new tab)

In vivo characterization and dynamic receptor occupancy imaging of TPA023B, an alpha 2/alpha 3/alpha 5 subtype selective gamma-aminobutyric acid-a partial agonist.

Provided suitable ligands and quantification methods are available for the appropriate target, quantitative PET offers a unique tool for dynamic in vivo measurement of relevant on-site receptor occupancy.
PubMed (opens in a new tab)

Synthesis and evaluation of two uncharged 99mTc‐labeled derivatives of thioflavin‐T as potential tracer agents for fibrillar brain amyloid

It is concluded that the studied 99mTc-labeled derivatives of thioflavin-T are not suitable as tracer agents for in vivo visualization of amyloid in brain.
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Evaluation of99mTc-complexes with novel monoamine diamide (MADA) thiolate tetraligands:L-cysteine acetyldiglycine diethyl ester andL-β-methylhomocysteinate acetyldiglycine ethyl ester

It may be concluded that the MADA-type ligands lose their amine proton upon complexation with 99m Tc resulting in hydrophilic, negatively charged 99M Tc-complexes which do not exhibit significant brain uptake in mice.
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Behavior of reaction mixtures under microwave conditions : use of sodium salts in microwave-induced N-[18F]fluoroalkylations of aporphine and tetralin derivatives

Microwave treatment combined with manipulation of the ionic strength of the reaction mixture increases the radiochemical yield dramatically of N-[F-18]fluoroalkylations of secondary amines as…
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Discovery of MK-3168: A clinical PET tracer as a target engagement biomarker for FAAH

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