Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster.
- A. Nemmar, H. Vanbilloen, M. Hoylaerts, P. Hoet, A. Verbruggen, B. Nemery
- Biology, MedicineAmerican Journal of Respiratory and Critical Care…
- 1 November 2001
A significant fraction of (99m)Tc-albumin, taken as a model of ultrafine particles, rapidly diffuses from the lungs into the systemic circulation, and lower values were observed in the heart, spleen, kidneys, and brain.
The Rules Governing Medicinal Products for Human Use in the European Union
- A. Verbruggen, I. Zolle
Comparison of diagnostic accuracy of 111In-pentetreotide SPECT and 68Ga-DOTATOC PET/CT: A lesion-by-lesion analysis in patients with metastatic neuroendocrine tumours
- S. Binnebeek, B. Vanbilloen, C. Deroose
- MedicineEuropean Radiology
- 1 March 2016
Ga-DOTATOC-PET/CT is superior for the detection of NET-metastases compared to 111In-pentetreotide SPECT, and PET is the scintigraphic method for accurate depiction of NET tumour burden.
Dual-tracer dopamine transporter and perfusion SPECT in differential diagnosis of parkinsonism using template-based discriminant analysis.
- K. Van Laere, C. Casteels, R. Dom
- MedicineJournal of Nuclear Medicine
- 1 March 2006
Dual-tracer DAT and perfusion SPECT in combination with discrimination analysis allows an automated, accurate differentiation between the most common forms of parkinsonism in a clinically relevant setting.
Optimal buffer choice of the radiosynthesis of 68Ga–Dotatoc for clinical application
- M. Bauwens, Rufael Chekol, H. Vanbilloen, G. Bormans, A. Verbruggen
- Biology, MedicineNuclear medicine communications
- 1 August 2010
Although the use of HEPES, acetate and succinate as buffering substances yielded comparable results, only acetate is currently recognized as a substance for pharmaceutical use and also for human use, and acetate buffer should be used for 68Ga–Dotatoc synthesis.
Fluoride kinetics of the axial skeleton measured in vivo with fluorine-18-fluoride PET.
- C. Schiepers, J. Nuyts, M. de Roo
- Medicine, BiologyJournal of Nuclear Medicine
- 1 December 1997
With PET and [18F]fluoride, local bone blood flow and fluoride influx rate can be quantified in patients in vivo and has potential for the monitoring of therapy response in metabolic bone disease.
Guideline to regulations for radiopharmaceuticals in early phase clinical trials in the EU
- A. Verbruggen, H. Coenen, C. Halldin
- MedicineEuropean Journal of Nuclear Medicine and…
- 9 August 2008
This guideline is to help investigators by giving an overview of relevant current EU requirements concerning the quality of starting materials and final drug products, the non-clinical safety studies and dosimetry considerations whilst designing a human clinical trial which includes the use of radiopharmaceutical compounds.
Technetium-99m-L,L-ethylenedicysteine: a renal imaging agent. I. Labeling and evaluation in animals.
- A. Verbruggen, D. Nosco, C. van Nerom, G. Bormans, P. Adriaens, M. D. de Roo
- Biology, ChemistryJournal of Nuclear Medicine
- 1 April 1992
The promising results of the animal experiments suggest that 99mTc-L,L-ethylenedicysteine may be a useful alternative to 99m Tc-MAG3 for renal function studies in humans.
Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia.
- V. Akurathi, L. Dubois, G. Bormans
- Chemistry, BiologyNuclear Medicine and Biology
- 1 July 2010
In vitro evaluation and biodistribution of a 99mTc-labeled anti-VEGF peptide targeting neuropilin-1.
- G. Perret, A. Starzec, J. Moretti
- Biology, ChemistryNuclear Medicine and Biology
- 1 July 2004