Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging

@article{Rosier1996VisualisationOL,
  title={Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging},
  author={A. Rosier and P. Dupont and J. Peuskens and G. Bormans and L. Mortelmans},
  journal={Psychiatry Research: Neuroimaging},
  year={1996},
  volume={68},
  pages={11-22}
}
We used [18F]altanserin and positron emission tomography (PET) to image serotonin 5-HT2A receptors in humans. The highest [18F]altanserin uptake is found in the cerebral cortex, with specific-to-nonspecific binding ratios varying from 0.53 to 1.91 in humans between 24 and 48 years of age. In all neocortical regions studied, [18F]altanserin uptake correlates negatively with age. No correlations were found between age and uptake in the cerebellum, the regional cerebral blood flow, or the time… Expand
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