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zoledronate

Known as: (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid, [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid, NDC-Zoledronate 
The brand name for zoledronic acid, a bisphosphonic imidazol compound which inhibits osteoclastic bone resorption. Although its mechanisms of action… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (4)

CGP 42446AZOL 446Zometazoledronic acid anhydrous
Pamidronate Disodiumcalcitriol/zoledronatecalcium carbonate/cholecalciferol/zoledronatedoxorubicin/goserelin/zoledronate

Broader (1)

zoledronic acid

Papers overview

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Review
2018
Review
2018
The why, when and how to test for obstructive sleep apnea in patients with atrial fibrillation
Sleep apnea is associated with increased cardiovascular risk and may be important in atrial fibrillation (AF) management. It is… 
2013
2013
Variations in nanomechanical properties and tissue composition within trabeculae from an ovine model of osteoporosis and treatment.
2007
2007
Anabolic effects of bisphosphonates on peri-implant bone stock.
Highly Cited
2005
Highly Cited
2005
Zoledronate inhibits proliferation and induces apoptosis of imatinib-resistant chronic myeloid leukaemia cells
Although imatinib mesylate has revolutionized the treatment of chronic myeloid leukaemia (CML), resistance to the drug… 
Highly Cited
2005
Highly Cited
2005
Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer.
Prostate cancer cells metastasize to the bone where their interaction with osteoclasts and osteoblasts can lead to alterations in… 
Highly Cited
2004
Highly Cited
2004
Breast tumour growth inhibition in vitro through the combination of cyclophosphamide/metotrexate/5-fluorouracil, epirubicin/cyclophosphamide, epirubicin/paclitaxel, and epirubicin/docetaxel with the…
Breast cancer has a significant capacity to metastasize to bone. Bisphosphonates are the standard treatment for hypocalcaemia of… 
2004
2004
Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition.
Clinical practice reveals that osteoporotic women treated with BPs (bisphosphonates) show an increased bone mass density and a… 
Review
2001
Review
2001
Analysis of skeletal-related events in breast cancer and response to therapy.
Highly Cited
2000
Highly Cited
2000
Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines
Bisphosphonates (BPs) are commonly used in the treatment of myeloma-associated osteolytic lesions. Recent reports have suggested… 
1993
1993
Liarozole and 13-cis-retinoic acid anti-prostatic tumor activity.
Liarozole fumarate (R85,246), a novel benzimidazole derivative, reduced s.c. and bone metastasis tumor growth by the androgen… 
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