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zinc-exporting ATPase activity

Known as: Zn2+-exporting ATPase activity, Zn(II)-translocating P-type ATPase activity, zinc exporting ATPase activity 
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) -> ADP… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis
Osteoarthritis (OA), primarily characterized by cartilage degeneration, is caused by an imbalance between anabolic and catabolic… Expand
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Highly Cited
2010
Highly Cited
2010
A Combined Zinc/Cadmium Sensor and Zinc/Cadmium Export Regulator in a Heavy Metal Pump*
Heavy metal pumps (P1B-ATPases) are important for cellular heavy metal homeostasis. AtHMA4, an Arabidopsis thaliana heavy metal… Expand
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Highly Cited
2009
Highly Cited
2009
A Common Highly Conserved Cadmium Detoxification Mechanism from Bacteria to Humans
Cadmium poses a significant threat to human health due to its toxicity. In mammals and in bakers' yeast, cadmium is detoxified by… Expand
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Highly Cited
2006
Highly Cited
2006
Zinc-Dependent Global Transcriptional Control, Transcriptional Deregulation, and Higher Gene Copy Number for Genes in Metal Homeostasis of the Hyperaccumulator Arabidopsis halleri1[W]
The metal hyperaccumulator Arabidopsis halleri exhibits naturally selected zinc (Zn) and cadmium (Cd) hypertolerance and… Expand
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Highly Cited
2005
Highly Cited
2005
The plant P1B‐type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels
The transition metal Zn is essential for many physiological processes in plants, yet at elevated concentrations this, and the… Expand
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Highly Cited
2005
Highly Cited
2005
Heavy metal transport by AtHMA4 involves the N‐terminal degenerated metal binding domain and the C‐terminal His11 stretch
The Arabidopsis thaliana AtHMA4 is a P1B‐type ATPase that clusters with the Zn/Cd/Pb/Co subgroup. It has been previously shown… Expand
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Highly Cited
2004
Highly Cited
2004
Overexpression of AtHMA4 enhances root‐to‐shoot translocation of zinc and cadmium and plant metal tolerance
AtHMA4 is an Arabidopsis thaliana P1B‐ATPase which transports Zn and Cd. Here, we demonstrate that AtHMA4 is localized at the… Expand
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Highly Cited
2004
Highly Cited
2004
A novel CPx‐ATPase from the cadmium hyperaccumulator Thlaspi caerulescens
Thlaspi caerulescens exhibits a unique capacity for cadmium tolerance and accumulation. We investigated the molecular basis of… Expand
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Highly Cited
2003
Highly Cited
2003
Functional expression of AtHMA4, a P1B-type ATPase of the Zn/Co/Cd/Pb subclass.
Mechanisms are required by all organisms to maintain the concentration of essential heavy metals (e.g. Zn and Cu) within… Expand
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Highly Cited
1994
Highly Cited
1994
Is Zn2+ transported by the mitochondrial calcium uniporter?
Zinc ions were found to inhibit Ca2+ uptake by rat liver mitochondria driven by succinate respiration but not that by a… Expand
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