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zatosetron maleate

Known as: 7-Benzofurancarboxamide, 5-Chloro-2,3-Dihydro-2,2-Dimethyl-N-(8-Methyl-8-Azabicyclo(3.2.1)Oct-3-yl)-, Endo-, (Z)-2-Butenedioate (1:1) 
National Institutes of Health

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LY 277359 maleate
zatosetron

Papers overview

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1999
1999
Pilot study of zatosetron (LY277359) maleate, a 5-hydroxytryptamine-3 antagonist, in the treatment of anxiety.
The aim of this study was to make a preliminary investigation of the efficacy and safety of zatosetron maleate, a selective 5… 
1995
1995
Antagonism of serotonin3 (5-HT3) receptors within the blood-brain barrier prevents cisplatin-induced emesis in dogs.
Recently discovered serotonin3 (5-HT3) receptor antagonists are potent antiemetics in cytotoxic drug-induced vomiting. The… 
1995
1995
Effect of CGS 25019C and other LTB4 antagonists in the mouse ear edema and rat neutropenia models
The pro-inflammatory lipid mediator leukotriene B 4 (LTB4) is derived from arachidonic acid (AA) metabolism through the… 
1994
1994
In vitro metabolism of zatosetron. Interspecies comparison and role of CYP 3A.
The major in vivo human metabolite of zatosetron is 8-alpha-methyl,8-beta-oxo zatosetron [N-O (1) zatosetron]. N-Desmethyl… 
1994
1994
Effect of Zatosetron on Ipecac‐Induced Emesis in Dogs and Healthy Men
Serotonin receptor (5‐HT3) antagonists provide effective antiemetic therapy in cancer patients receiving emetogenic chemotherapy… 
1992
1992
Zatosetron, a potent, selective, and long-acting 5HT3 receptor antagonist: synthesis and structure-activity relationships.
Antagonists of 5HT3 receptors are clinically effective in treating nausea and emesis associated with certain oncolytic drugs… 
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