Effect of Zatosetron on Ipecac‐Induced Emesis in Dogs and Healthy Men

@article{Schwartz1994EffectOZ,
  title={Effect of Zatosetron on Ipecac‐Induced Emesis in Dogs and Healthy Men},
  author={Steven M. Schwartz and Mark J. Goldberg and Jaswant S. Gidda and Benito J. Cerimele},
  journal={The Journal of Clinical Pharmacology},
  year={1994},
  volume={34}
}
Serotonin receptor (5‐HT3) antagonists provide effective antiemetic therapy in cancer patients receiving emetogenic chemotherapy, such as cisplatin. Animal studies have shown that 5‐HT3 receptor antagonists also have antiemetic activity in ipecac‐induced emesis. The authors investigated the antiemetic activity of zatosetron maleate, a 5‐HT3 receptor antagonist, on ipecac‐induced emesis in dogs and healthy men. They also evaluated the effect of ipecac administration on serotonin release and… 
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Vomiting and Nausea

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