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yuanhuadine

 
National Institutes of Health

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Broader (1)

Terpenes

Papers overview

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2019
2019
Overcoming the Intrinsic Gefitinib-resistance via Downregulation of AXL in Non-small Cell Lung Cancer
Background Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is a limited… Expand
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2018
2018
Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used clinically as target therapies for lung cancer… Expand
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2018
2018
BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells
Lung cancer is the leading cause of cancer-associated deaths worldwide. In particular, non-small-cell lung cancer (NSCLC) cells… Expand
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2016
2016
Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions
The failure of targeted therapy due to the resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs… Expand
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Highly Cited
2015
Highly Cited
2015
Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, remains a… Expand
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2012
2012
[The incompatibility mechanism based on the interaction of multiple-components for Flos Genkwa and Radix et Rhizoma Glycyrrhizae].
By investigating the interaction between components from Flos Genkwa (FG) and Radix et Rhizoma Glycyrrhizae (RRG) and the… Expand
2011
2011
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
The growth inhibition and antitumor activities of yuanhuadine (1), a daphnane diterpenoid from the flowers of Daphne genkwa, were… Expand
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2010
2010
Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa.
Two new daphnane-type diterpene esters, yuanhuahine (1) and yuanhualine (2), were isolated from the flowers of Daphne genkwa… Expand
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Highly Cited
2006
Highly Cited
2006
Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure-activity relationship of potent inhibitory activity against DNA topoisomerase I.
Two new daphne diterpene esters Yuanhuajine (2) and Yuanhuagine (4), together with three known daphne diterpene esters… Expand
1981
1981
STUDIES ON THE ACTIVE PRINCIPLES OF THE ROOT OF YUAN-HUA (DAPHNE GENKWA) II. ISOLATION AND STRUCTURE OF A NEW ANTIFERTILE DITERPENE YUANHUADINE
A new diterpene orthoester, Yuanhuadine C_(32)H_(42)O_(10), M~+m/z 586.2790, [a]_D~(16.5)+26.9°(c. 0.045 CHCl_3)was isolated from… Expand
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