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yuanhuadine

 
National Institutes of Health

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Terpenes

Papers overview

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2018
2018
Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used clinically as target therapies for lung cancer… Expand
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2018
2018
BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells
Lung cancer is the leading cause of cancer-associated deaths worldwide. In particular, non-small-cell lung cancer (NSCLC) cells… Expand
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2016
2016
Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions
The failure of targeted therapy due to the resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs… Expand
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2015
2015
Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, remains a… Expand
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2014
2014
Cytotoxic Daphnane-Type Diterpenoids from Daphne genkwa
Daphne genkwa Sieb. et Zucc., a shrub of the Thymelaeaceae family, is widely distributed in China. Its flower buds have been used… Expand
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2012
2012
[The incompatibility mechanism based on the interaction of multiple-components for Flos Genkwa and Radix et Rhizoma Glycyrrhizae].
By investigating the interaction between components from Flos Genkwa (FG) and Radix et Rhizoma Glycyrrhizae (RRG) and the… Expand
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2011
2011
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
The growth inhibition and antitumor activities of yuanhuadine (1), a daphnane diterpenoid from the flowers of Daphne genkwa, were… Expand
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2010
2010
Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa.
Two new daphnane-type diterpene esters, yuanhuahine (1) and yuanhualine (2), were isolated from the flowers of Daphne genkwa… Expand
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2006
2006
Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure-activity relationship of potent inhibitory activity against DNA topoisomerase I.
Two new daphne diterpene esters Yuanhuajine (2) and Yuanhuagine (4), together with three known daphne diterpene esters… Expand
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1981
1981
STUDIES ON THE ACTIVE PRINCIPLES OF THE ROOT OF YUAN-HUA (DAPHNE GENKWA) II. ISOLATION AND STRUCTURE OF A NEW ANTIFERTILE DITERPENE YUANHUADINE
A new diterpene orthoester, Yuanhuadine C_(32)H_(42)O_(10), M~+m/z 586.2790, [a]_D~(16.5)+26.9°(c. 0.045 CHCl_3)was isolated from… Expand
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