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willardiine

Known as: (S)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidine propanoic acid, 3-(Uracil-1-yl)-L-alanine, beta-(2,4-dihydroxypyrimidin-1-yl)alanine 
 
National Institutes of Health

Papers overview

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Highly Cited
2011
2008
2008
The mechanism by which the binding of a neurotransmitter to a receptor leads to channel opening is a central issue in molecular… Expand
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Highly Cited
2007
Highly Cited
2007
Some N3-substituted analogues of willardiine such as 11 and 13 are selective kainate receptor antagonists. In an attempt to… Expand
2006
2006
N3-substitution of the uracil ring of willardiine with a variety of carboxyalkyl or carboxybenzyl substituents produces AMPA and… Expand
2005
2005
The natural product willardiine (8) is an AMPA receptor agonist while 5-iodowillardiine (10) is a selective kainate receptor… Expand
Highly Cited
2004
Highly Cited
2004
Willardiine derivatives with an N3-benzyl substituent bearing an acidic group have been synthesized with the aim of producing… Expand
Highly Cited
1997
Highly Cited
1997
Both willardiine and azawillardiine analogs (18-28) have been reported to be potent and selective agonists for either AMPA or… Expand
1995
1995
This study examined the binding of (S)-[3H]AMPA, the radiolabelled active isomer of AMPA, to rat brain synaptic membranes. Under… Expand
Highly Cited
1994
Highly Cited
1994
Concentration jump responses to 5-substituted (S)-willardiines were recorded from dorsal root ganglion (DRG) and hippocampal… Expand
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Highly Cited
1992
Highly Cited
1992
Willardiine [(S)-1-(2-amino-2-carboxyethyl)pyrimidine-2,4-dione] is a naturally occurring heterocyclic excitatory amino acid… Expand
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