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willardiine

Known as: (S)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidine propanoic acid, 3-(Uracil-1-yl)-L-alanine, beta-(2,4-dihydroxypyrimidin-1-yl)alanine 
National Institutes of Health

Related topics

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3 relations

Broader (2)

AlanineUracil
analogs & derivatives

Papers overview

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2015
2015
A quantum biochemistry investigation of willardiine partial agonism in AMPA receptors.
We employ quantum biochemistry methods based on the Density Functional Theory (DFT) approach to unveil the detailed binding… 
2009
2009
Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
Ionotropic glutamate receptors mediate the majority of vertebrate excitatory synaptic transmission. The development of selective… 
Highly Cited
2008
Highly Cited
2008
Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution.
The mechanism by which the binding of a neurotransmitter to a receptor leads to channel opening is a central issue in molecular… 
2006
2006
3-Hydroxypyridazine 1-oxides as carboxylate bioisosteres: A new series of subtype-selective AMPA receptor agonists
2006
2006
Cell cycle-dependent regulation of kainate-induced inward currents in microglia.
1998
1998
Pharmacological differentiation of kainate receptors on neonatal rat spinal motoneurones and dorsal roots
Highly Cited
1998
Highly Cited
1998
Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine.
Characterization of the role of kainate receptors in excitatory synaptic transmission has been hampered by a lack of subtype… 
Highly Cited
1997
Highly Cited
1997
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
Both willardiine and azawillardiine analogs (18-28) have been reported to be potent and selective agonists for either AMPA or… 
Highly Cited
1992
Highly Cited
1992
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine
Willardiine [(S)-1-(2-amino-2-carboxyethyl)pyrimidine-2,4-dione] is a naturally occurring heterocyclic excitatory amino acid… 
1972
1972
Biosynthesis of willardiine and isowillardiine in germinating pea seeds and seedlings.
The synthesis of the pyrimidinyl amino acids willardiine and isowillardiine was studied in vivo and in vitro. Uracil derivatives… 
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