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vinzolidine

Known as: 2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-16-methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-, methyl ester, (3R-(3R*,5S*,7R*,9S*))- 
An orally active semisynthetic vinca alkaloid with potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine binds to and… 
National Institutes of Health

Related topics

Related topics

3 relations
Microtubule ProcessVinzolidine Sulfate

Broader (1)

Vinca Alkaloids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Interactions of human leukocyte interferon with vinca alkaloids and other chemotherapeutic agents against human tumors in clonogenic assay
SummaryPurified human leukocyte interferon produced by recombinant techniques (IFN-αA) was tested in vitro with chemotherapeutic… 
2004
2004
Antitumor activity of vinzolidine in the human tumor clonogenic assay and comparison with vinblastine
SummaryVinzolidine (VZL), a semisynthetic vinblastine (VLB) derivative, was tested against a variety of solid tumors in the human… 
2004
2004
Oral vinzolidine as therapy for Kaposi's sarcoma and carcinomas of lung, breast, and colon/rectum
SummaryVinzolidine, a semisynthetic vinca alkaloid, was studied as oral therapy in 30 patients with Kaposi's sarcoma, non-small… 
2004
2004
Five-day schedule of vinzolidine, an oral vinca alkaloid, in a variety of tumors
SummaryThis Phase I–II trial evaluated vinzolidine (VZL), a semisynthetic vinblastine derivative administered on a five-day oral… 
2004
2004
A phase I and pharmacokinetic study of intravenous vinzolidine
SummaryThe semi-synthetic vinca alkaloid vinzolidine was administered to advanced cancer patients as an intravenous bolus on a… 
1990
1990
Phase I trial of intravenous vinzolidine (LY 104208) given on a biweekly dosing schedule
SummaryVinzolidine (VZL) is a semisynthetic vinca alkaloid with broad antitumor activity in animal models of malignancy but had… 
1985
1985
In vitro comparison of vinzolidine and vinblastine: a model for methods of evaluation of analogues in a human tumor cloning system.
Four statistical techniques are described for comparing the in vitro cytotoxic activity of an analogue and its parent compound in… 
1984
1984
Phase II trial of vinzolidine, an oral vinca alkaloid, in Hodgkin's disease and non-Hodgkin's lymphoma.
Vinzolidine, a semisynthetic vinblastine derivative, was tested in an oral formulation in 21 heavily pretreated patients with… 
1984
1984
Phase I trial of vinzolidine.
Vinzolidine is a new, orally active, semisynthetic vinca alkaloid which shows broad anti-tumor activity against murine tumor test… 
Review
1984
Review
1984
Review of Phase I-II Clinical Trials with Vinzolidine (VZL), A New Orally Active Semisynthetic Vinblastine Derivative
Vinzolidine is a semisynthetic oxazolidinedione derivative of vinblastine (Figure 1). It was chosen for clinical development… 
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