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vinzolidine

Known as: 2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-16-methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-, methyl ester, (3R-(3R*,5S*,7R*,9S*))- 
An orally active semisynthetic vinca alkaloid with potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine binds to and… 
National Institutes of Health

Related topics

Related topics

3 relations
Microtubule ProcessVinzolidine Sulfate

Broader (1)

Vinca Alkaloids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1986
1986
Predictive Assays of Clinical Response for Primary and Metastatic Colorectal Cancer
An in vitro soft agar cloning technique was utilized to attempt to culture 762 patients’ colorectal carcinoma tissue samples… 
1985
1985
In vitro comparison of vinzolidine and vinblastine: a model for methods of evaluation of analogues in a human tumor cloning system.
Four statistical techniques are described for comparing the in vitro cytotoxic activity of an analogue and its parent compound in… 
1984
1984
Phase II trial of vinzolidine, an oral vinca alkaloid, in Hodgkin's disease and non-Hodgkin's lymphoma.
Vinzolidine, a semisynthetic vinblastine derivative, was tested in an oral formulation in 21 heavily pretreated patients with… 
1984
1984
Phase I trial of vinzolidine.
Vinzolidine is a new, orally active, semisynthetic vinca alkaloid which shows broad anti-tumor activity against murine tumor test… 
Review
1984
Review
1984
Review of Phase I-II Clinical Trials with Vinzolidine (VZL), A New Orally Active Semisynthetic Vinblastine Derivative
Vinzolidine is a semisynthetic oxazolidinedione derivative of vinblastine (Figure 1). It was chosen for clinical development… 
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