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vindoline

Known as: (2 beta,3 beta,4 beta,5 alpha,12 beta,19 alpha)- 4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy- 1-methylaspidospermidine-3-carboxylic acid, (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid 
An indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly. (NCI)
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Vinblastine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Methyljasmonate accelerates catabolism of monoterpenoid indole alkaloids in Catharanthus roseus during leaf processing.
1995
1995
Anti-calmodulin potency of indol alkaloids in in vitro systems.
Review
1994
Review
1994
Large-scale insect and plant cell culture.
Highly Cited
1988
Highly Cited
1988
Enzymic coupling of catharanthine and vindoline to form 3',4'-anhydrovinblastine by horseradish peroxidase.
Etude du mecanisme de la reaction de condensation de la catharanthine avec la vindoline, catalysee par la peroxidase. Un… 
1985
1985
One-electron oxidation of vindoline and 16-O-acetylvindoline catalyzed by peroxidase.
The mechanism of oxidation of the alkaloids vindoline (1) and 16-O-acetylvindoline (1a) was examined by use of the reversible… 
1982
1982
Microbial transformations of natural antitumor agents XVIII: Conversions of vindoline with copper oxidases.
Vindoline occurs structurally intact in the clinically important Vinca alkaloids vinblastine and vincristine. It is oxidized by… 
1981
1981
Effects of vinca alkaloids on calcium-calmodulin regulated cyclic adenosine 3' ,5'-monophosphatase phosphodiesterase activity from brain.
Highly Cited
1978
Highly Cited
1978
Structure-activity relationships of dimeric Catharanthus alkaloids. 1. Deacetylvinblastine amide (vindesine) sulfate.
Exploration of the effects of "minor" structural differences on the antitumor activity and toxicity of dimeric Catharanthus… 
1975
1975
Regulation of secondary metabolism in higher plants. Effect of alkaloids on a cytochrome P-450 dependent monooxygenase.
Highly Cited
1967
Highly Cited
1967
Biosynthesis of the indole and colchicum alkaloids
Abstract 
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