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vindoline

Known as: (2 beta,3 beta,4 beta,5 alpha,12 beta,19 alpha)- 4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy- 1-methylaspidospermidine-3-carboxylic acid, (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid 
An indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly. (NCI)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Significance Bioinformatics and virus-induced gene silencing (VIGS)-guided gene discovery combined with biochemical enzyme assays… Expand
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Highly Cited
2011
Highly Cited
2011
Vindoline constitutes the main terpenoid indole alkaloid accumulated in leaves of Catharanthus roseus, and four genes involved in… Expand
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Highly Cited
2010
Highly Cited
2010
A concise asymmetric total synthesis of (-)-vindoline (1) is detailed based on a tandem intramolecular [4+2]/[3+2] cycloaddition… Expand
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Highly Cited
2010
Highly Cited
2010
Concise asymmetric total syntheses of vindoline (1) and vindorosine (2) are detailed based on a unique intramolecular [4 + 2]/[3… Expand
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Highly Cited
2008
Highly Cited
2008
A direct coupling of cantharanthine with vindoline to provide vinblastine is detailed along with key mechanistic and labeling… Expand
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Highly Cited
2005
Highly Cited
2005
[reaction: see text] Two exceptionally concise total syntheses of (-)- and ent-(+)-vindoline are detailed enlisting a… Expand
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Highly Cited
2004
Highly Cited
2004
A 2-oxoglutarate-dependent dioxygenase (EC 1.14.11.11) which catalyzes the 4-hydroxylation of desacetoxyvindoline was purified to… Expand
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Highly Cited
2002
Highly Cited
2002
Two direct HPLC analytical methods for the screening of the major indole alkaloids of Catharanthus roseus hairy roots and their… Expand
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Highly Cited
1988
Highly Cited
1988
Multidrug resistance (MDR), typified by resistance to Vinca alkaloids and anthracyclines, is a well characterized experimental… Expand
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Review
1963
Review
1963
Summary A phytochemical investigation of the plant Vinca rosea Linn. has demonstrated that a number of alkaloidal substances can… Expand
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