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vicriviroc

A piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. Vicriviroc is designed to bind to CCR5 and inhibit… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The roles of the chemokine CCL5 and its receptor CCR5 in breast cancer progression remain unclear. Here, we conducted microarray… Expand
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2010
2010
BACKGROUND Agents that block the CCR5 coreceptor for human immunodeficiency virus (HIV) have demonstrated potent antiretroviral… Expand
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Highly Cited
2009
Highly Cited
2009
High-throughput sequencing platforms provide an approach for detecting rare HIV-1 variants and documenting more fully… Expand
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2009
2009
Vicriviroc (VCV) is a small-molecule CCR5 coreceptor antagonist currently in clinical trials for treatment of R5-tropic human… Expand
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Highly Cited
2008
Highly Cited
2008
Little is known about the in vivo development of resistance to human immunodeficiency virus type 1 (HIV-1) CCR5 antagonists. We… Expand
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Highly Cited
2008
Highly Cited
2008
Several small molecule drugs that bind to the host CCR5 co-receptor and prevent viral entry have been developed for the treatment… Expand
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Highly Cited
2008
Highly Cited
2008
In addition to being an important receptor in leukocyte activation and mobilization, CCR5 is the essential coreceptor for human… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Vicriviroc, an investigational CCR5 inhibitor, demonstrated short-term antiretroviral activity in a phase 1 study… Expand
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE To determine antiviral activity, pharmacokinetic properties, and safety of vicriviroc, an orally available CCR5… Expand
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Highly Cited
2005
Highly Cited
2005
Inhibiting human immunodeficiency virus type 1 (HIV-1) infection by blocking the host cell coreceptors CCR5 and CXCR4 is an… Expand
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