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vaniprevir

National Institutes of Health

Papers overview

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2017
2017
We introduce the ForceGen method for 3D structure generation and conformer elaboration of drug-like small molecules. ForceGen is… 
2017
2017
A phase separation/continuous flow strategy employing an oxidative Glaser-Hay coupling of alkynes has been applied toward the… 
2015
2015
AbstractBackgroundVaniprevir is a potent macrocyclic hepatitis C virus (HCV) nonstructural protein 3/4A protease inhibitor. This… 
2015
2015
Background Some drugs that are actively taken up into the liver exhibit greater than dose proportional increases in plasma… 
Highly Cited
2014
2014
2014
BackgroundVaniprevir (MK-7009) is a hepatitis C virus (HCV) non-structural 3/4a protease inhibitor which significantly increases… 
Highly Cited
2012
Highly Cited
2012
Vaniprevir (MK‐7009) is a macrocyclic hepatitis C virus (HCV) nonstructural protein 3/4A protease inhibitor. The aim of the… 
Highly Cited
2012
Highly Cited
2012
Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including… 
Highly Cited
2012
Highly Cited
2012
A highly efficient synthesis of Vaniprevir (MK-7009) has been accomplished in nine linear steps and 55% overall yield. The key… 
Highly Cited
2011
Highly Cited
2011
BACKGROUND & AIMS The hepatitis C virus (HCV) genotype influences efficacy of interferon (IFN)-based therapy. HCV protease…