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MK-7009

Known as: MK 7009, MK7009 
 
National Institutes of Health

Papers overview

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2013
2013
BACKGROUND & AIMS MK-7009 (vaniprevir) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease… Expand
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Highly Cited
2012
Highly Cited
2012
A highly efficient synthesis of Vaniprevir (MK-7009) has been accomplished in nine linear steps and 55% overall yield. The key… Expand
2011
2011
Development of a practical synthesis of MK-7009, a 20-membered [corrected] macrocycle, is described. A variety of ring-closing… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND & AIMS The hepatitis C virus (HCV) genotype influences efficacy of interferon (IFN)-based therapy. HCV protease… Expand
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Highly Cited
2010
Highly Cited
2010
A new class of HCV NS3/4a protease inhibitors which contain a P2 to P4 macrocyclic constraint was designed using a molecular… Expand
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Highly Cited
2010
Highly Cited
2010
ABSTRACT In order to assess the natural variation in susceptibility to hepatitis C virus (HCV) NS3 protease inhibitors (PIs… Expand
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Highly Cited
2010
Highly Cited
2010
ABSTRACT Efforts to develop novel, interferon-sparing therapies for treatment of chronic hepatitis C (HCV) infection are… Expand
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Highly Cited
2009
Highly Cited
2009
ABSTRACT The administration of hepatitis C virus (HCV) NS3/4A protease inhibitors to patients with chronic HCV infections has… Expand
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2009
2009
MK-7009 Significantly Improves Rapid Viral Response (RVR) in Combination with Pegylated Interferon Alfa-2a and Ribavirin in… Expand
2009
2009
HPLC-MS/MS methods for the determination of a Hepatitis C NS3/NS4 protease inhibitor (MK-7009) in human plasma and Tween-treated… Expand