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MK-7009

Known as: MK 7009, MK7009 
National Institutes of Health

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2 relations

Broader (1)

Indoles
vaniprevir

Papers overview

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2016
2016
Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice.
2015
2015
Liver-to-Plasma Vaniprevir (MK-7009) Concentration Ratios in HCV-Infected Patients
Background Some drugs that are actively taken up into the liver exhibit greater than dose proportional increases in plasma… 
2014
2014
P1228 COMPARATIVE RESISTANCE ANALYSIS BETWEEN CIRRHOTIC AND NON-CIRRHOTIC TREATMENT EXPERIENCED PATIENTS WHO FAILED TREATMENT WITH A COMBINATION OF VANIPREVIR (MK-7009) AND PEGYLATED INTERFERON AND…
2013
2013
106 SUSTAINED VIRAL RESPONSE AND SAFETY OF MK-7009 IN CIRRHOTIC TREATMENT-EXPERIENCED PATIENTS WITH GENOTYPE 1 HCV INFECTION WHO HAVE FAILED PREVIOUS PEGYLATED INTERFERON AND RIBAVIRIN TREATMENT
2011
2011
Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.
Development of a practical synthesis of MK-7009, a 20-membered [corrected] macrocycle, is described. A variety of ring-closing… 
2011
2011
Efficacy and safety of MK-7009 in combination with Peg-IFN and ribavirin therapy in the retreatment of patients with chronic hepatitis C genotype 1 with a high viral load
Highly Cited
2010
Highly Cited
2010
Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents
ABSTRACT Efforts to develop novel, interferon-sparing therapies for treatment of chronic hepatitis C (HCV) infection are… 
2009
2009
Effect of disease state on ionization during bioanalysis of MK-7009, a selective HCV NS3/NS4 protease inhibitor, in human plasma and human Tween-treated urine by high-performance liquid…
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