valganciclovir

Known as: VGCV, L-valine, ester with ganciclovir, ganciclovir L-valyl ester 
A synthetic prodrug of ganciclovir, a nucleoside analogue of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Elevated immune activation persists during treated human immunodeficiency virus (HIV) infection and is associated with… (More)
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Highly Cited
2010
Highly Cited
2010
Late-onset cytomegalovirus (CMV) disease is a significant problem with a standard 3-month prophylaxis regimen. This multicentre… (More)
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Highly Cited
2007
Highly Cited
2007
Intravenous ganciclovir is the standard treatment for cytomegalovirus disease in solid organ transplant recipients. Oral… (More)
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Highly Cited
2007
Highly Cited
2007
Both preemptive therapy and universal prophylaxis are used to prevent cytomegalovirus (CMV) disease after transplantation… (More)
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Highly Cited
2006
Highly Cited
2006
Prophylaxis reduces cytomegalovirus (CMV) disease, but is associated with increased costs and risks for side effects, viral… (More)
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Highly Cited
2004
Highly Cited
2004
We compared the efficacy and safety of valganciclovir with those of oral ganciclovir in preventing cytomegalovirus (CMV) disease… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Valganciclovir is an orally administered prodrug that is rapidly hydrolyzed to ganciclovir. We compared the effects of… (More)
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Highly Cited
2000
Highly Cited
2000
The pharmacokinetics of an orally administered valine ester of ganciclovir (GCV), valganciclovir (VGC), were studied. These were… (More)
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Highly Cited
2000
Highly Cited
2000
In clinical trials, valganciclovir, the valyl ester of ganciclovir, has been shown to enhance the bioavailability of ganciclovir… (More)
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