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undecaprenyl pyrophosphate synthetase

Known as: di-trans, poly-cis-decaprenylcistransferase, undecaprenyl PP synthetase, undecaprenyl diphosphate synthase 
 
National Institutes of Health

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uppS protein, E coli

Papers overview

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2016
2016
Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.
We synthesized a series of benzoic acids and phenylphosphonic acids and investigated their effects on the growth of… Expand
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2015
2015
Antibacterial drug leads: DNA and enzyme multitargeting.
We report the results of an investigation of the activity of a series of amidine and bisamidine compounds against Staphylococcus… Expand
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2015
2015
A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.
With the rise in antibiotic resistance, there is interest in discovering new drugs active against new targets. Here, we… Expand
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2014
2014
Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads
There is a significant need for new antibiotics due to the rise in drug resistance. Drugs such as methicillin and vancomycin… Expand
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2012
2012
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl… Expand
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Highly Cited
2007
Highly Cited
2007
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS… Expand
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Highly Cited
2001
Highly Cited
2001
Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase.
Undecaprenyl diphosphate synthase (UPS) catalyzes the cis-prenyl chain elongation onto trans, trans-farnesyl diphosphate (FPP) to… Expand
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1982
1982
Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase.
Undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase were partially purified and characterized from… Expand
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1980
1980
Prenyl transferases from Micrococcus luteus: characterization of undecaprenyl pyrophosphate synthetase.
Abstract Three prenyl transferases in Micrococcus luteus were recovered in the soluble fraction following cell disruption… Expand
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1974
1974
Characterization of undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum.
Abstract A soluble long-chain polyprenyl pyrophosphate synthetase has been isolated from Lactobacillus plantarum and partially… Expand
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