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undecaprenyl pyrophosphate synthetase

Known as: di-trans, poly-cis-decaprenylcistransferase, undecaprenyl PP synthetase, undecaprenyl diphosphate synthase 
National Institutes of Health

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uppS protein, E coli

Papers overview

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Review
2016
Review
2016
cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases*
cis-Prenyltransferases (cis-PTs) constitute a large family of enzymes conserved during evolution and present in all domains of… 
2016
2016
Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase
We synthesized a series of benzoic acids and phenylphosphonic acids and investigated their effects on the growth of… 
2016
2016
Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase.
We report the first X-ray structure of the unique "head-to-middle" monoterpene synthase, lavandulyl diphosphate synthase (LPPS… 
2015
2015
Antibacterial drug leads: DNA and enzyme multitargeting.
We report the results of an investigation of the activity of a series of amidine and bisamidine compounds against Staphylococcus… 
Review
2012
Review
2012
Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis.
2012
2012
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl… 
Highly Cited
2007
Highly Cited
2007
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS… 
Highly Cited
2001
Highly Cited
2001
Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase
Undecaprenyl diphosphate synthase (UPS) catalyzes the cis-prenyl chain elongation onto trans, trans-farnesyl diphosphate (FPP) to… 
Highly Cited
1982
Highly Cited
1982
Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase.
Undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase were partially purified and characterized from… 
1980
1980
Prenyl transferases from Micrococcus luteus: characterization of undecaprenyl pyrophosphate synthetase.
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