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undecaprenyl pyrophosphate synthetase

Known as: di-trans, poly-cis-decaprenylcistransferase, undecaprenyl PP synthetase, undecaprenyl diphosphate synthase 
National Institutes of Health

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uppS protein, E coli

Papers overview

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Review
2016
Review
2016
cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases*
cis-Prenyltransferases (cis-PTs) constitute a large family of enzymes conserved during evolution and present in all domains of… 
2016
2016
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth
We synthesized potential inhibitors of farnesyl diphosphate synthase (FPPS), undecaprenyl diphosphate synthase (UPPS), or… 
2015
2015
Antibacterial drug leads: DNA and enzyme multitargeting.
We report the results of an investigation of the activity of a series of amidine and bisamidine compounds against Staphylococcus… 
2015
2015
A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer‐aided Drug Discovery
With the rise in antibiotic resistance, there is interest in discovering new drugs active against new targets. Here, we… 
2014
2014
Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads
There is a significant need for new antibiotics due to the rise in drug resistance. Drugs such as methicillin and vancomycin… 
Review
2012
Review
2012
Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis.
Highly Cited
2007
Highly Cited
2007
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS… 
Highly Cited
2001
Highly Cited
2001
Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase
Undecaprenyl diphosphate synthase (UPS) catalyzes the cis-prenyl chain elongation onto trans, trans-farnesyl diphosphate (FPP) to… 
Highly Cited
1982
Highly Cited
1982
Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase.
Undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase were partially purified and characterized from… 
1974
1974
Characterization of undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum.
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