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Septicaemic melioidosis in a tertiary care hospital in south India.
BACKGROUND & OBJECTIVES Melioidosis and the causative organism Burkholderia pseudomallei are being recognized gradually in various centres in India. In the septicaemic form, melioidosis is a seriousExpand
Flavonoid from Carica papaya inhibits NS2B-NS3 protease and prevents Dengue 2 viral assembly
Dengue virus belongs to the virus family Flaviviridae. Dengue hemorrhagic disease caused by dengue virus is a public health problem worldwide. The viral non structural 2B and 3 (NS2B-NS3) proteaseExpand
Discerning molecular interactions: A comprehensive review on biomolecular interaction databases and network analysis tools.
Computational analysis of biomolecular interaction networks is now gaining a lot of importance to understand the functions of novel genes/proteins. Gene interaction (GI) network analysis andExpand
Computational Analysis Reveals the Association of Threonine 118 Methionine Mutation in PMP22 Resulting in CMT-1A
TLDR
The T118M mutation in PMP22 gene is associated with Charcot Marie Tooth, type 1A (CMT1A), the most common inherited disorder of the peripheral nervous system. Expand
β-Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies
Background Pyrazolones are traditionally synthesized by the reaction of β-keto esters with hydrazine and its derivatives. There are methods to synthesize β-keto esters from esters and aldehydes, butExpand
Computation of non-covalent interactions in TNF proteins and interleukins.
The roles played by the non-covalent interactions have been investigated for a set of six TNF proteins and nine Interleukins. The stabilizing residues have been identified by a consensus approachExpand
Exploring the role of cation-pi interactions in glycoproteins lipid-binding proteins and RNA-binding proteins.
We have analyzed and compared the influence of cation-pi interactions in glycoproteins (GPs), lipid-binding proteins (LBPs) and RNA-binding proteins (RBPs) in this study. We observed that all theExpand
Investigations on C-H...pi interactions in RNA binding proteins.
We have investigated the roles played by C-Hcdots, three dots, centeredpi interactions in RNA binding proteins. There was an average of 55 C-Hcdots, three dots, centeredpi interactions per proteinExpand
Exploring the resistance mechanism of imipenem in carbapenem hydrolysing class D beta-lactamases OXA-143 and its variant OXA-231 (D224A) expressing Acinetobacter baumannii: An in-silico approach
TLDR
Acinetobacter baumannii has acquired resistance to imipenem due to the secretion of carbapenem hydrolysing class D beta-lactamases. Expand
Insights on inhibition of Plasmodium falciparum plasmepsin I by novel epoxyazadiradione derivatives – molecular docking and comparative molecular field analysis
Abstract In the present study, we have explored the anti-malarial potential of epoxyazadiradione, the natural entity extracted from the neem seed oil and its chemical derivatives, against PlasmodiumExpand
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