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The mechanisms involved in the epithelial to mesenchymal transition (EMT) are integrated in concert with master developmental and… Expand Insulin receptors are highly enriched at neuronal synapses, but whose function remains unclear. Here we present evidence that… Expand There is considerable evidence that the epidermal growth factor receptor (EGFR) and IGF-I receptor (IGF-IR) cross-talk in breast… Expand Hepatocellular carcinoma (HCC) is one of the most common cancer-related causes of death worldwide. In light of the very poor 5… Expand Insulin‐like growth factor binding protein (IGFBP)‐3 has both growth‐inhibiting and growth‐promoting effects at the cellular… Expand De novo and acquired resistance to the anti-tumour drug gefitinib (ZD1839; Iressa), a specific epidermal growth factor receptor… Expand IntroductionGefitinib (Iressa, ZD 1839, AstraZeneca) blocks the tyrosine kinase activity of the epidermal growth factor receptor… Expand We investigated the role of receptor tyrosine kinases in Ang II-stimulated generation of reactive oxygen species (ROS) and… Expand Metformin decreases endogenous glucose production by the liver. Few studies have examined the effect of metformin on the insulin… Expand Insulin-like growth factor-1 (IGF-1) plays an important growth-promoting effect by activating the PI3K/Akt signalling pathway… Expand