tumor infiltrating lymphocyte therapy

Known as: TIL, therapy, tumor infiltrating lymphocyte 
A form of adoptive cell transfer in which lymphocytes are isolated from a patient's tumor, grown in vitro, and then infused into the patient in… (More)
National Institutes of Health

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Broader (1)

Immunotherapy
Lymphocytes, Tumor-Infiltrating

Papers overview

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Highly Cited
2015
Highly Cited
2015
Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma.
BACKGROUND Immune checkpoint inhibitors targeting programmed cell death 1 (PD1) or its ligand (PD-L1) showed activity in several… (More)
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Highly Cited
2015
Highly Cited
2015
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.
Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in complete regression of advanced… (More)
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Highly Cited
2012
Highly Cited
2012
Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma.
PURPOSE To determine whether density and distribution of tumor-infiltrating lymphocytes (TILs; TIL grade) is an independent… (More)
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2010
2010
Tumor infiltrating lymphocyte therapy for metastatic melanoma: analysis of tumors resected for TIL.
Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) can mediate objective tumor regression in 49% to 72% of patients… (More)
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Highly Cited
2010
Highly Cited
2010
Selection of CD8+PD-1+ lymphocytes in fresh human melanomas enriches for tumor-reactive T cells.
CD8+ tumor-infiltrating lymphocytes (TILs) in human melanomas express high levels of PD-1 and are functionally impaired. However… (More)
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Highly Cited
2004
Highly Cited
2004
Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression.
The authors describe a patient who experienced recurrence of metastatic melanoma after an initial dramatic response to… (More)
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Highly Cited
1996
Highly Cited
1996
TIL: A Type-Directed Optimizing Compiler for ML
We describe a new compiler for Standard ML called TIL, that is based on four technologies: intensional polymorphism, tag-free… (More)
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Highly Cited
1995
Highly Cited
1995
Prolonged disease-free period in patients with advanced epithelial ovarian cancer after adoptive transfer of tumor-infiltrating lymphocytes.
Thirteen patients with epithelial ovarian cancer, who did not show any detectable lesion after cisplatin-containing chemotherapy… (More)
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Highly Cited
1994
Highly Cited
1994
Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx
WE report here the identification of a unique vertebrate nuclear receptor, Tlx, which is expressed exclusively in the… (More)
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Highly Cited
1988
Highly Cited
1988
Autologous tumor-specific cytotoxic T lymphocytes in the infiltrate of human metastatic melanomas. Activation by interleukin 2 and autologous tumor cells, and involvement of the T cell receptor
TIL from metastatic melanoma proliferated by greater than 1,000-fold (840-3,675, mean 1,543) after 6 wk in culture of mixtures of… (More)
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