FAQ

Lymphocytes, Tumor-Infiltrating

Known as: Tumor Infiltrating Lymphocyte, Tumor-Infiltrating Lymphocyte, Tumor-Infiltrating Lymphocytes 
Lymphocytes that show specificity for autologous tumor cells. Ex vivo isolation and culturing of TIL with interleukin-2, followed by reinfusion into… (More)

Topic mentions per year

Topic mentions per year

1976-2018
05010015019762018

Related topics

Related topics

12 relations
Adoptive ImmunotherapyHematopoietic and Lymphoid TissueLymphoid TissueMicrobiological
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Broader (2)

Cytotoxic T-LymphocytesLymphocyte

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Lymphocytes, Tumor-Infiltrating
physiological aspects
Lymphocyte
Cytotoxic T-Lymphocytes
Lymphoid Tissue
Microbiological

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial.
BACKGROUND We have previously shown the prognostic importance of tumor-infiltrating lymphocytes (TILs) in newly diagnosed triple… (More)
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Highly Cited
2011
Highly Cited
2011
Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer
Infiltration of breast tumors by tumor-infiltrating lymphocytes (TIL) has been associated with sensitivity to anthracycline-based… (More)
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Highly Cited
2009
Highly Cited
2009
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.
Tumor antigen-specific T cells are found within melanomas, yet tumors continue to grow. Although the tumor microenvironment is… (More)
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Highly Cited
2006
Highly Cited
2006
Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes.
Cell-based antitumor immunity is driven by CD8(+) cytotoxic T cells bearing TCR that recognize specific tumor-associated peptides… (More)
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Highly Cited
2003
Highly Cited
2003
Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients.
The generation of T lymphocytes with specific reactivity against tumor antigens is a prerequisite for effective adoptive transfer… (More)
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Highly Cited
1998
Highly Cited
1998
The Fas counterattack in vivo: apoptotic depletion of tumor-infiltrating lymphocytes associated with Fas ligand expression by human esophageal carcinoma.
Various cancer cell lines express Fas ligand (FasL) and can kill lymphoid cells by Fas-mediated apoptosis in vitro. FasL… (More)
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Highly Cited
1996
Highly Cited
1996
A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes
A number of antigens recognized by tumor-reactive T cells have recently been identified. The antigens identified in mouse model… (More)
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Highly Cited
1994
Highly Cited
1994
Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes
Four melanoma proteins, MART-1, gp100, tyrosinase, and tyrosinase-related protein-1 (gp75) were evaluated for recognition by HLA… (More)
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Highly Cited
1989
Highly Cited
1989
Tumor-specific cytolysis by lymphocytes infiltrating human melanomas.
Tumor infiltrating lymphocytes (TIL) were grown in IL-2 from single cell tumor suspensions of 14 human melanomas resected from 12… (More)
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Highly Cited
1986
Highly Cited
1986
A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes.
The adoptive transfer of tumor-infiltrating lymphocytes (TIL) expanded in interleukin-2 (IL-2) to mice bearing micrometastases… (More)
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