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Lymphocytes, Tumor-Infiltrating

Known as: Tumor Infiltrating Lymphocyte, Tumor-Infiltrating Lymphocyte, Tumor-Infiltrating Lymphocytes 
Lymphocytes that show specificity for autologous tumor cells. Ex vivo isolation and culturing of TIL with interleukin-2, followed by reinfusion into… Expand
National Institutes of Health

Related topics

Related topics

14 relations
Adoptive ImmunotherapyHematopoietic and Lymphoid TissueLymphoid TissueMAGE-12: 170-178 Peptide
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Broader (2)

Cytotoxic T-LymphocytesLymphocyte

Papers overview

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Review
2019
Review
2019
Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment
Immune checkpoint inhibitor (ICI) activates host’s anti-tumor immune response by blocking negative regulatory immune signals. A… Expand
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Review
2019
Review
2019
Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis
ABSTRACT Tumor-infiltrating lymphocytes (TILs) are associated with prognosis in various tumors. However, it remains controversial… Expand
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Highly Cited
2014
Highly Cited
2014
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors.
Adoptive transfer of tumor-infiltrating lymphocytes (TILs) can mediate regression of metastatic melanoma; however, TILs are a… Expand
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Highly Cited
2014
Highly Cited
2014
Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial.
BACKGROUND We have previously shown the prognostic importance of tumor-infiltrating lymphocytes (TILs) in newly diagnosed triple… Expand
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Highly Cited
2005
Highly Cited
2005
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.
In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203-213], the presence of CD3+ tumor-infiltrating lymphocytes… Expand
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Highly Cited
2004
Highly Cited
2004
B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression
Purpose: B7-H1/PD-L1 (B7-H1) and B7-DC/PD-L2 (B7-DC) are ligands for the receptor PD-1, which is known to negatively regulate T… Expand
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Highly Cited
1994
Highly Cited
1994
Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2.
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of… Expand
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Highly Cited
1994
Highly Cited
1994
Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.
By cDNA expression cloning we have isolated a gene encoding a shared human melanoma antigen recognized by HLA-A2 restricted… Expand
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Highly Cited
1988
Highly Cited
1988
Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report.
Lymphocytes extracted from freshly resected melanomas can be expanded in vitro and can often mediate specific lysis of autologous… Expand
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Highly Cited
1986
Highly Cited
1986
A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes.
The adoptive transfer of tumor-infiltrating lymphocytes (TIL) expanded in interleukin-2 (IL-2) to mice bearing micrometastases… Expand
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