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tucaresol

Known as: 4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid, Benzoic acid, 4-((2-formyl-3-hydroxyphenoxy)methyl)- 
National Institutes of Health

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4 relations

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589C80BW 589C

Broader (2)

BenzaldehydesBenzoates

Papers overview

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Review
2016
Review
2016
Translation from SCD Mouse to Man: Chronic Administration of Tucaresol Reduces RBC Sickling and Improves Hematological Parameters, but Does Not Impact Inflammatory Markers in SCD Model Mice
Sickle cell disease is a hematological disorder with significant unmet need that affects approximately ten million people… 
2014
2014
Tucaresol down-modulation of MUC1-stimulated human mononuclear cells
Interaction between antigen presenting cells and T lymphocytes, through receptors and co-stimulatory molecules present on the… 
2005
2005
Analysis of the env V3 sequences obtained from patients with HIV type 1 infection treated with the immune modulant agent tucaresol.
Tucaresol, a Schiff base-forming compound that is shown to enhance cytotoxic T cell responses and the production of type 1… 
2002
2002
Marked Enhancement of the Antigen-Specific Immune Response by Combining Plasmid DNA-Based Immunization with a Schiff Base-Forming Drug
ABSTRACT Although plasmid DNA (pDNA)-based immunization has proven efficacy, the level of immune responses that is achieved by… 
2001
2001
Schiff base‐mediated co‐stimulation primes the T‐cell‐receptor‐dependent calcium signalling pathway in CD4 T cells
In addition to macromolecular interactions that provide co‐stimulation during antigen‐presenting cell (APC) and CD4+ T‐cell… 
1998
1998
Effect of food and gender on the pharmacokinetics of tucaresol in healthy volunteers.
AIMS The potential effects of food and gender on the pharmacokinetics of tucaresol were investigated in healthy volunteers… 
1997
1997
Convergence of Schiff base costimulatory signaling and TCR signaling at the level of mitogen-activated protein kinase ERK2.
Schiff base formation on specialized T cell surface amines provides a costimulatory signal to T cells through a mechanism that… 
Review
1996
Review
1996
Covalent chemical events in immune induction: fundamental and therapeutic aspects.
1995
1995
Pharmacokinetics and pharmacodynamics of tucaresol, an antisickling agent, in healthy volunteers.
1. Tucaresol is an orally administered antisickling agent which increases the oxygen affinity of haemoglobin. 2. The… 
1995
1995
The exploratory clinical development of tucaresol, an antisickling agent, using a novel surrogate marker
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