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tripterine

Known as: 3-hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid, celastrol 
National Institutes of Health

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Triterpenes

Papers overview

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2018
2018
Protective effects of celastrol against γ irradiation-induced oxidative stress in human umbilical vein endothelial cells
High-dose ionizing radiation can cause harmful effects on the cardiovascular system. Notably, endothelial cells are critical… 
2013
2013
Regiochemistry discoveries in the use of isoxazole as a handle for the rapid construction of an all-carbon macrocyclic precursor in the synthetic studies of celastrol.
We have developed a convergent synthetic route to an all-carbon, 14-membered Z,E-macrocyclic bis-enone during our synthetic study… 
2013
2013
Proteasome inhibition protects human peripheral blood mononuclear cells from radiation-induced oxidative stress
Abstract Purpose: The study aimed to analyze the impact of the proteasome inhibitors MG132 (N-carbobenzyoxyl-L-leucyl-L-leucyl-L… 
2012
2012
Preparation of tripterine nanostructured lipid carriers and their absorption in rat intestine.
The purpose of this study was to develop an optimized nanostructured lipid carrier formulation (NLC) for tripterine, and to… 
2010
2010
MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules
SummaryTargeting cellular mitosis is an attractive antitumor strategy. Here, we reported MT7, a novel compound from the 6H-Pyrido… 
2008
2008
Inhibition of Anthrax Lethal Toxin-Induced Cytolysis of RAW264.7 Cells by Celastrol
Background Bacillus anthracis is the bacterium responsible for causing anthrax. The ability of B. anthracis to cause disease is… 
2004
2004
[The experimental study on the inhibitory effect of tripterine on airway inflammation in asthmatic mice].
OBJECTIVE To investigate the effect and mechanism of tripterine on airway inflammation in asthmatic mice. METHODS 30 BALB/c… 
1997
1997
Effect of tripterine on collagen-induced arthritis in rats.
AIM To study the therapeutic effect of tripterine (Tri) on collagen-induced arthritis (CIA). METHODS Collagen type II (Col) 1.5… 
1990
1990
[Immunosuppressive and antiinflammatory activities of tripterine].
Tripterine is one of the active components isolated from Tripterygium wilfordii Hook.f. In this study tripterine was shown to… 
1980
1980
The cathedulin alkaloids.
Studies on fresh and dried leaf and shoot material of Catha edulis (khat) collected in Ethiopia, Kenya and the Yemen Arab… 
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