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tripchlorolide
Known as:
tryptolide-12,13-chlorohydrin
, Bisoxireno(4b,5:8a,9)phenanthro(1,2-c)furan-4(2H)-one, 11-chloro-1b,3,6,6b,7,7a,9,10,11,11a-decahydro-9,10-dihydroxy-1b-methyl-10-(1-methylethyl)-, (1bS-(1aR*,1balpha,6bbeta,7abeta,8aR*,9alpha,10beta,11alpha,11abeta))-
, TW397
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Diterpenes
Phenanthrenes
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells
Li-min Chen
,
T. Song
,
Jian Xiao
,
Zhenghui Huang
,
Yong Li
,
Ting-yan Lin
Oncotarget
2017
Corpus ID: 54486721
Tripchlorolide (T4) has been shown to induce A549 lung cancer cell death predominantly by activating an autophagy pathway…
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2015
2015
A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis.
Yan Li
,
Jinghui Wang
,
+5 authors
Shuwei Zhang
Journal of ethnopharmacology
2015
Corpus ID: 27145280
2015
2015
Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse‐related proteins in a transgenic model of Alzheimer's Disease
Yuqi Zeng
,
Jian Zhang
,
+8 authors
Xiaochun Chen
Journal of neurochemistry
2015
Corpus ID: 206090625
Alzheimer's disease (AD) is characterized by early impairments in memory and progressive neurodegeneration. Disruption of…
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Review
2012
Review
2012
Tripterygium wilfordii bioactive compounds as anticancer and anti‐inflammatory agents
Kwong-Fai Wong
,
Yi Yuan
,
J. Luk
Clinical and experimental pharmacology…
2012
Corpus ID: 1485094
1. Bioactive compounds from medicinal plants with anticancer and anti‐inflammatory effects have become key resources in drug…
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2012
2012
Tripchlorolide induces cell death in lung cancer cells by autophagy
Limin Chen
,
Qing Liu
,
+4 authors
Ting-yan Lin
International journal of oncology
2012
Corpus ID: 16528481
It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents tumor growth…
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Highly Cited
2009
Highly Cited
2009
Tripchlorolide protects neuronal cells from microglia‐mediated β‐amyloid neurotoxicity through inhibiting NF‐κB and JNK signaling
Xiao-dong Pan
,
Xiao-Chun Chen
,
+5 authors
Hua-pin Huang
Glia
2009
Corpus ID: 27499674
Recent research has focused on soluble oligomeric assemblies of β‐amyloid peptides (Aβ) as the proximate cause of…
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2007
2007
Tripchlorolide protects against MPTP‐induced neurotoxicity in C57BL/6 mice
Zhen Hong
,
G. Wang
,
+4 authors
S. Chen
The European journal of neuroscience
2007
Corpus ID: 41956776
Many current studies of Parkinson's disease (PD) suggest that inflammation is involved in the neurodegenerative process…
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Highly Cited
2003
Highly Cited
2003
Neurotrophic and Neuroprotective Effects of Tripchlorolide, an Extract of Chinese Herb Tripterygium wilfordii Hook F, on Dopaminergic Neurons
Feng-qiao Li
,
Xiao-xin Cheng
,
+5 authors
Jisheng Han
Experimental Neurology
2003
Corpus ID: 16430070
It has been reported recently that the immunosuppressant FK506 produced neurotrophic and neuroprotective effects on dopaminergic…
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1999
1999
Effects of tripchlorolide on the epididymides and testes of rats.
Z. P. Wang
,
Z. Gu
,
+4 authors
S. Qian
Asian journal of andrology
1999
Corpus ID: 38845933
AIM To further evaluate the antifertility effects of tripchlorolide, a derivative of triptolide produced at the extraction…
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1990
1990
[The isolation and structure of tripchlorolide (T4) from Tripterygium wilfordii].
X. Lu
Zhongguo yi xue ke xue yuan xue bao. Acta…
1990
Corpus ID: 30814355
A new compound named tripchlorolide was isolated from Total Glucosides (T II) extracted from the woody part of the root of…
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