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tripchlorolide

Known as: tryptolide-12,13-chlorohydrin, Bisoxireno(4b,5:8a,9)phenanthro(1,2-c)furan-4(2H)-one, 11-chloro-1b,3,6,6b,7,7a,9,10,11,11a-decahydro-9,10-dihydroxy-1b-methyl-10-(1-methylethyl)-, (1bS-(1aR*,1balpha,6bbeta,7abeta,8aR*,9alpha,10beta,11alpha,11abeta))-, TW397 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

DiterpenesPhenanthrenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse‐related proteins in a transgenic model of Alzheimer's Disease
Alzheimer's disease (AD) is characterized by early impairments in memory and progressive neurodegeneration. Disruption of… Expand
2015
2015
A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis.
ETHNOPHARMACOLOGY RELEVANCE The angiogenesis control at the initiation of rheumatoid arthritis (RA) that mainly blocks the… Expand
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2014
2014
Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice
Deficits in cognition and performance accompanying age-related neurodegenerative diseases such as Alzheimer's disease (AD) are… Expand
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Review
2012
Review
2012
Tripterygium wilfordii bioactive compounds as anticancer and anti‐inflammatory agents
1. Bioactive compounds from medicinal plants with anticancer and anti‐inflammatory effects have become key resources in drug… Expand
2012
2012
Tripchlorolide induces cell death in lung cancer cells by autophagy
It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents tumor growth… Expand
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Highly Cited
2009
Highly Cited
2009
Tripchlorolide protects neuronal cells from microglia‐mediated β‐amyloid neurotoxicity through inhibiting NF‐κB and JNK signaling
Recent research has focused on soluble oligomeric assemblies of β‐amyloid peptides (Aβ) as the proximate cause of… Expand
2008
2008
Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia.
A large body of evidence has suggested a strong association between neuroinflammation and the pathogenesis of many… Expand
2007
2007
Tripchlorolide protects against MPTP‐induced neurotoxicity in C57BL/6 mice
Many current studies of Parkinson's disease (PD) suggest that inflammation is involved in the neurodegenerative process… Expand
Highly Cited
2003
Highly Cited
2003
Neurotrophic and Neuroprotective Effects of Tripchlorolide, an Extract of Chinese Herb Tripterygium wilfordii Hook F, on Dopaminergic Neurons
  • Feng-Qiao Li, Xiao-Xin Cheng, +5 authors Ji-sheng Han
  • Experimental Neurology
  • 2003
    • Corpus ID: 16430070
It has been reported recently that the immunosuppressant FK506 produced neurotrophic and neuroprotective effects on dopaminergic… Expand
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1999
1999
Effects of tripchlorolide on the epididymides and testes of rats.
AIM To further evaluate the antifertility effects of tripchlorolide, a derivative of triptolide produced at the extraction… Expand
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