FAQ

tripchlorolide

Known as: tryptolide-12,13-chlorohydrin, Bisoxireno(4b,5:8a,9)phenanthro(1,2-c)furan-4(2H)-one, 11-chloro-1b,3,6,6b,7,7a,9,10,11,11a-decahydro-9,10-dihydroxy-1b-methyl-10-(1-methylethyl)-, (1bS-(1aR*,1balpha,6bbeta,7abeta,8aR*,9alpha,10beta,11alpha,11abeta))-, TW397 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2016
02419902016

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2 relations

Broader (2)

DiterpenesPhenanthrenes

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
tripchlorolide
Diterpenes
Phenanthrenes

Papers overview

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2014
2014
Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice.
Deficits in cognition and performance accompanying age-related neurodegenerative diseases such as Alzheimer's disease (AD) are… (More)
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2012
2012
Tripchlorolide induces cell death in lung cancer cells by autophagy
It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents… (More)
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2009
2009
Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling.
Recent research has focused on soluble oligomeric assemblies of beta-amyloid peptides (Abeta) as the proximate cause of… (More)
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2008
2008
Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia.
A large body of evidence has suggested a strong association between neuroinflammation and the pathogenesis of many… (More)
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2007
2007
Tripchlorolide protects against MPTP-induced neurotoxicity in C57BL/6 mice.
Many current studies of Parkinson's disease (PD) suggest that inflammation is involved in the neurodegenerative process… (More)
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2003
2003
Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons.
It has been reported recently that the immunosuppressant FK506 produced neurotrophic and neuroprotective effects on dopaminergic… (More)
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2002
2002
[Protective effect of tripchlorolide on dopaminergic neurons in partially lesioned rat model of Parkinson's disease].
AIM To study whether the immunosuppressant tripchlorolide (T4) exerts neuroprotective effect on dopaminergic neurons. METHODS A… (More)
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1999
1999
Effects of tripchlorolide on the epididymides and testes of rats.
AIM To further evaluate the antifertility effects of tripchlorolide, a derivative of triptolide produced at the extraction… (More)
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1995
1995
[Study on antifertility mechanisms of tripchlorolide (T4)].
  • X. Zuo, N. Wang
  • Zhongguo yi xue ke xue yuan xue bao. Acta…
  • 1995
Hyaluronidase activities of testes and epididymides in rats were obviously inhibited by T4 po at dosage of 0.1 mg.kg-1/d for 7… (More)
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1994
1994
Antispermatogenic effect of Tripterygium wilfordii and tripchlorolide (T4) on rat gametogenesis and spermatozoa.
The multiglycosides of Tripterygium wilfordii (TII), a ready-made Chinese herbal medicine used for the treatment of rheumatoid… (More)
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