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tripchlorolide

Known as: tryptolide-12,13-chlorohydrin, Bisoxireno(4b,5:8a,9)phenanthro(1,2-c)furan-4(2H)-one, 11-chloro-1b,3,6,6b,7,7a,9,10,11,11a-decahydro-9,10-dihydroxy-1b-methyl-10-(1-methylethyl)-, (1bS-(1aR*,1balpha,6bbeta,7abeta,8aR*,9alpha,10beta,11alpha,11abeta))-, TW397 
 
National Institutes of Health

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2 relations

Broader (2)

DiterpenesPhenanthrenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells.
Tripchlorolide (T4) has been shown to induce A549 lung cancer cell death predominantly by activating an autophagy pathway… Expand
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2015
2015
Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease.
Alzheimer's disease (AD) is characterized by early impairments in memory and progressive neurodegeneration. Disruption of… Expand
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2014
2014
Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice
Deficits in cognition and performance accompanying age-related neurodegenerative diseases such as Alzheimer's disease (AD) are… Expand
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Review
2012
Review
2012
Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents.
1. Bioactive compounds from medicinal plants with anticancer and anti-inflammatory effects have become key resources in drug… Expand
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2012
2012
Tripchlorolide induces cell death in lung cancer cells by autophagy
It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents… Expand
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2009
2009
Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling.
Recent research has focused on soluble oligomeric assemblies of beta-amyloid peptides (Abeta) as the proximate cause of… Expand
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2008
2008
Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia.
A large body of evidence has suggested a strong association between neuroinflammation and the pathogenesis of many… Expand
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2007
2007
Tripchlorolide protects against MPTP-induced neurotoxicity in C57BL/6 mice.
Many current studies of Parkinson's disease (PD) suggest that inflammation is involved in the neurodegenerative process… Expand
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2003
2003
Neurotrophic and Neuroprotective Effects of Tripchlorolide, an Extract of Chinese Herb Tripterygium wilfordii Hook F, on Dopaminergic Neurons
It has been reported recently that the immunosuppressant FK506 produced neurotrophic and neuroprotective effects on dopaminergic… Expand
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1999
1999
Effects of tripchlorolide on the epididymides and testes of rats.
AIM To further evaluate the antifertility effects of tripchlorolide, a derivative of triptolide produced at the extraction… Expand
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