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tripchlorolide

Known as: tryptolide-12,13-chlorohydrin, Bisoxireno(4b,5:8a,9)phenanthro(1,2-c)furan-4(2H)-one, 11-chloro-1b,3,6,6b,7,7a,9,10,11,11a-decahydro-9,10-dihydroxy-1b-methyl-10-(1-methylethyl)-, (1bS-(1aR*,1balpha,6bbeta,7abeta,8aR*,9alpha,10beta,11alpha,11abeta))-, TW397 
National Institutes of Health

Related topics

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2 relations

Broader (2)

DiterpenesPhenanthrenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells
Tripchlorolide (T4) has been shown to induce A549 lung cancer cell death predominantly by activating an autophagy pathway… 
2015
2015
A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis.
2015
2015
Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse‐related proteins in a transgenic model of Alzheimer's Disease
Alzheimer's disease (AD) is characterized by early impairments in memory and progressive neurodegeneration. Disruption of… 
Review
2012
Review
2012
Tripterygium wilfordii bioactive compounds as anticancer and anti‐inflammatory agents
1. Bioactive compounds from medicinal plants with anticancer and anti‐inflammatory effects have become key resources in drug… 
2012
2012
Tripchlorolide induces cell death in lung cancer cells by autophagy
It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents tumor growth… 
Highly Cited
2009
Highly Cited
2009
Tripchlorolide protects neuronal cells from microglia‐mediated β‐amyloid neurotoxicity through inhibiting NF‐κB and JNK signaling
Recent research has focused on soluble oligomeric assemblies of β‐amyloid peptides (Aβ) as the proximate cause of… 
2007
2007
Tripchlorolide protects against MPTP‐induced neurotoxicity in C57BL/6 mice
Many current studies of Parkinson's disease (PD) suggest that inflammation is involved in the neurodegenerative process… 
Highly Cited
2003
Highly Cited
2003
Neurotrophic and Neuroprotective Effects of Tripchlorolide, an Extract of Chinese Herb Tripterygium wilfordii Hook F, on Dopaminergic Neurons
It has been reported recently that the immunosuppressant FK506 produced neurotrophic and neuroprotective effects on dopaminergic… 
1999
1999
Effects of tripchlorolide on the epididymides and testes of rats.
AIM To further evaluate the antifertility effects of tripchlorolide, a derivative of triptolide produced at the extraction… 
1990
1990
[The isolation and structure of tripchlorolide (T4) from Tripterygium wilfordii].
  • X. Lu
  • Zhongguo yi xue ke xue yuan xue bao. Acta…
  • 1990
  • Corpus ID: 30814355
A new compound named tripchlorolide was isolated from Total Glucosides (T II) extracted from the woody part of the root of… 
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